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|Title: ||Synthesis and characterization of divinyl-fumarate Poly-ε-caprolactone for scaffolds with controlled architectures|
|Authors: ||Ronca, A.|
De Santis, R.
|Keywords: ||Photocrosslinkable polymer|
Mathematically defined scaffold
|Issue Date: ||2016|
|Citation: ||RONCA, A. ... et al, 2016. Synthesis and characterization of divinyl-fumarate Poly-ε-caprolactone for scaffolds with controlled architectures. Journal of Tissue Engineering and Regenerative Medicine, doi:10.1002/term.2322.|
|Abstract: ||A vinyl-terminated Polycaprolactone has been developed for tissue engineering applications using a one-step synthesis and functionalization method based on Ring Opening Polymerization (ROP) of ԑ-caprolactone, with Hydroxyl Ethyl Vinyl Ether (HEVE) acting both as the initiator of ROP and as photo-curable functional group. The proposed method employs a catalyst based on Al, instead of the most popular Tin(II) 2-ethylhexanoate, to reduce the cytotoxicity. Following the synthesis of the vinyl-terminated polycaprolactone, its reaction with Fumaryl Chloride (FuCl) results in a divinyl-fumarate polycaprolactone (VPCLF). The obtained polymers were thoroughly characterized using Fourier Transform Infrared Spectroscopy (FTIR) and gel permeation chromatography (GPC) techniques. The polymer has been successfully employed, in combination with N-vinyl Pyrrolidone (NVP), to fabricate films and computer-designed porous scaffolds by micro-stereolithography (μ-SL) with Gyroid and Diamond architectures. Characterization of the networks indicated the influence of NVP content on the network properties. Human Mesenchymal Stem Cells (hMSCs) adhered and spread onto VPCLF/NVP networks showing good biological properties and no cytotoxic effect.|
|Description: ||This paper is closed access until 30th September 2017.|
|Version: ||Accepted for publication|
|Publisher Link: ||http://dx.doi.org/10.1002/term.2322|
|Appears in Collections:||Closed Access (Materials)|
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