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Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/22831

Title: Synthesis and characterization of divinyl-fumarate Poly-ε-caprolactone for scaffolds with controlled architectures
Authors: Ronca, A.
Ronca, Sara
Forte, Giuseppe
Zeppetelli, S.
Gloria, A.
De Santis, R.
Ambrosio, L.
Keywords: Photocrosslinkable polymer
Polycaprolactone fumarate
Biocompatibility
Stereolithography
Cell-material interactions
Mathematically defined scaffold
Issue Date: 2016
Publisher: Wiley
Citation: RONCA, A. ... et al, 2016. Synthesis and characterization of divinyl-fumarate Poly-ε-caprolactone for scaffolds with controlled architectures. Journal of Tissue Engineering and Regenerative Medicine, doi:10.1002/term.2322.
Abstract: A vinyl-terminated Polycaprolactone has been developed for tissue engineering applications using a one-step synthesis and functionalization method based on Ring Opening Polymerization (ROP) of ԑ-caprolactone, with Hydroxyl Ethyl Vinyl Ether (HEVE) acting both as the initiator of ROP and as photo-curable functional group. The proposed method employs a catalyst based on Al, instead of the most popular Tin(II) 2-ethylhexanoate, to reduce the cytotoxicity. Following the synthesis of the vinyl-terminated polycaprolactone, its reaction with Fumaryl Chloride (FuCl) results in a divinyl-fumarate polycaprolactone (VPCLF). The obtained polymers were thoroughly characterized using Fourier Transform Infrared Spectroscopy (FTIR) and gel permeation chromatography (GPC) techniques. The polymer has been successfully employed, in combination with N-vinyl Pyrrolidone (NVP), to fabricate films and computer-designed porous scaffolds by micro-stereolithography (μ-SL) with Gyroid and Diamond architectures. Characterization of the networks indicated the influence of NVP content on the network properties. Human Mesenchymal Stem Cells (hMSCs) adhered and spread onto VPCLF/NVP networks showing good biological properties and no cytotoxic effect.
Description: This paper is closed access until 30th September 2017.
Version: Accepted for publication
DOI: 10.1002/term.2322
URI: https://dspace.lboro.ac.uk/2134/22831
Publisher Link: http://dx.doi.org/10.1002/term.2322
ISSN: 1932-7005
Appears in Collections:Closed Access (Materials)

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