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|Title: ||Fabrication and characterisation of 3D complex hydroxyapatite scaffolds with hierarchical porosity of different features for optimal bioactive performance|
|Authors: ||Chen, Zhichao|
Wragg, Nicholas M.
Lewis, Mark P.
|Keywords: ||Hydroxyapatite scaffold|
Bone tissue engineering
|Issue Date: ||2016|
|Publisher: ||© Elsevier|
|Citation: ||CHEN, Z. ... et al, 2016. Fabrication and characterisation of 3D complex hydroxyapatite scaffolds with hierarchical porosity of different features for optimal bioactive performance. Ceramics International, 43 (1 Part A), pp.336-344.|
|Abstract: ||To improve the biological performance of hydroxyapatite scaffolds in bone tissue engineering, graphite was used as porogen to create additional micro/nanoporosity to macroporosity, resulting in hierarchical porosity. For maximum imitation of natural bone structures, scaffolds with different porosity features were fabricated using micron/nano-sized graphite. The sintering profile of graphite treated scaffolds was optimised to reduce the influence of shrinkage. To confirm the porosity features, the micro/nanostructures of scaffolds were characterised by scanning electron microscopy and Brunauer-Emmett-Teller method. Considering that hydroxyapatite is resistant to biodegradation in vivo, the degradation rate of scaffolds in modified simulated body fluid was examined. Furthermore, biological evaluations based on myoblasts were carried out to investigate the influence of porosity features on the essential performance such as adhesion, proliferation and differentiation. The results indicate that the scaffolds with dominant microporosity and little nanoporosity formed inside had high potential for clinical applications due to improved performance in bioactivity.|
|Description: ||This paper was accepted for publication in the journal Ceramics International and the definitive published version is available at http://dx.doi.org/10.1016/j.ceramint.2016.09.160.|
|Sponsor: ||National Natural Science Foundation of China (Nos. 81371939 and 31270150) and State Key Lab of Materials Processing and Die & Mould
Technology (No. 2014-5).|
|Version: ||Accepted for publication|
|Publisher Link: ||http://dx.doi.org/10.1016/j.ceramint.2016.09.160|
|Appears in Collections:||Published Articles (Mechanical, Electrical and Manufacturing Engineering)|
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