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Title: Iatrogenic menopause after treatment for cervical cancer
Authors: Moss, E.L.
Taneja, S.
Munir, Fehmidah
Kent, C.
Robinson, L.
Potdar, N.
Sarhanis, P.
McDermott, Hilary
Keywords: Cervical cancer
Hormone replacement therapy
Iatrogenic menopause
Premature ovarian failure
Radiotherapy
Issue Date: 2016
Publisher: © Published by Elsevier Ltd on behalf of The Royal College of Radiologists.
Citation: MOSS, E.L. ... et al., 2016. Iatrogenic menopause after treatment for cervical cancer. Clinical Oncology, 28 (12), pp. 766 - 775.
Abstract: The ever-improving prognosis of women diagnosed with cervical cancer has meant that survivorship and treatment-related sequelae are being brought more into the spotlight in an attempt to try to reduce morbidity and improve women's long-term health. However, there are many issues surrounding an iatrogenic menopause in cervical cancer, a variety of potential management options and barriers to treatment. Women who have become menopausal under the age of 45 years as a result of cervical cancer are significantly less likely to start hormone replacement therapy (HRT) or continue it long term as compared with those who have undergone a surgical menopause for a benign reason. High profile media reports raising concerns about the safety of HRT use have left many women reluctant to consider HRT as a therapeutic option for menopausal symptoms and many are seeking to use complementary/alternative medicine, including non-pharmacological interventions, to alleviate symptoms. The benefits of HRT in this population have been shown to reduce these effects, although adherence to treatment regimens is a challenge due to poor compliance, which is in part due to the fear of a second malignancy. The development of non-HRT-based interventions to ameliorate menopausal symptoms and reduce the long-term health consequences are needed for women who choose not to take HRT.
Description: This article was published in the journal Clinical Oncology [© Published by Elsevier Ltd on behalf of The Royal College of Radiologists] and the definitive version is available at: http://dx.doi.org/10.1016/j.clon.2016.08.016
Version: Accepted for publication
DOI: 10.1016/j.clon.2016.08.016
URI: https://dspace.lboro.ac.uk/2134/23447
Publisher Link: http://dx.doi.org/10.1016/j.clon.2016.08.016
ISSN: 0936-6555
Appears in Collections:Published Articles (Sport, Exercise and Health Sciences)

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