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Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/23469

Title: DROPLAY: laser writing of functional patterns within biological microdroplet displays
Authors: Chan, Chi Long
Bolognesi, Guido
Bhandarkar, Archis
Friddin, Mark S.
Brooks, Nicholas J.
Seddon, John M.
Law, Robert V.
Barter, Laura M.C.
Ces, Oscar
Issue Date: 2016
Publisher: Royal Society of Chemistry
Citation: CHAN, C.L. ... et al, 2016. DROPLAY: laser writing of functional patterns within biological microdroplet displays. Lab on a Chip, 16 (23), pp. 4621 - 4627
Abstract: In this study, we introduce an optofluidic method for the rapid construction of large-area cell-sized droplet assemblies with user-defined, re-writable, two-dimensional patterns of functional droplets. Light responsive water-in-oil droplets capable of releasing fluorescent dye molecules upon exposure were generated and self-assembled into arrays inside a microfluidic device. This biological architecture was exploited by the scanning laser of a confocal microscope to ‘write’ user defined patterns of differentiated (fluorescent) droplets in a network of originally undifferentiated (non-fluorescent) droplets. As a result, long lasting images were produced on a droplet fabric with droplets acting as pixels of a biological monitor, which can be erased and re-written on-demand. Regio-specific light-induced droplet differentiation within a large population of droplets provides a new paradigm for the rapid construction of bio-synthetic systems with potential as tissue mimics and biological display materials.
Description: This is an open access article published by the Royal Society of Chemistry and distributed under the terms of the Creative Commons Attribution Licence (CC BY 3.0), https://creativecommons.org/licenses/by/3.0/
Sponsor: This research was funded by EP/J017566/1, EP/L015498/1 and EP/K503733/1 grants.
Version: Published
DOI: 10.1039/C6LC01219A
URI: https://dspace.lboro.ac.uk/2134/23469
Publisher Link: http://dx.doi.org/10.1039/C6LC01219A
ISSN: 1473-0197
Appears in Collections:Published Articles (Chemical Engineering)

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