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|Title: ||DROPLAY: laser writing of functional patterns within biological microdroplet displays|
|Authors: ||Chan, Chi Long|
Friddin, Mark S.
Brooks, Nicholas J.
Seddon, John M.
Law, Robert V.
Barter, Laura M.C.
|Issue Date: ||2016|
|Publisher: ||Royal Society of Chemistry|
|Citation: ||CHAN, C.L. ... et al, 2016. DROPLAY: laser writing of functional patterns within biological microdroplet displays. Lab on a Chip, 16 (23), pp. 4621 - 4627|
|Abstract: ||In this study, we introduce an optofluidic method for the rapid construction of large-area cell-sized droplet assemblies with user-defined, re-writable, two-dimensional patterns of functional droplets. Light responsive water-in-oil droplets capable of releasing fluorescent dye molecules upon exposure were generated and self-assembled into arrays inside a microfluidic device. This biological architecture was exploited by the scanning laser of a confocal microscope to ‘write’ user defined patterns of differentiated (fluorescent) droplets in a network of originally undifferentiated (non-fluorescent) droplets. As a result, long lasting images were produced on a droplet fabric with droplets acting as pixels of a biological monitor, which can be erased and re-written on-demand. Regio-specific light-induced droplet differentiation within a large population of droplets provides a new paradigm for the rapid construction of bio-synthetic systems with potential as tissue mimics and biological display materials.|
|Description: ||This is an open access article published by the Royal Society of Chemistry and distributed under the terms of the Creative Commons Attribution Licence (CC BY 3.0), https://creativecommons.org/licenses/by/3.0/|
|Sponsor: ||This research was funded by EP/J017566/1,
EP/L015498/1 and EP/K503733/1 grants.|
|Publisher Link: ||http://dx.doi.org/10.1039/C6LC01219A|
|Appears in Collections:||Published Articles (Chemical Engineering)|
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