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Title: Implementing silicon nanoribbon field-effect transistors as arrays for multiple ion detection
Authors: Stoop, Ralph L.
Wipf, Mathias
Muller, Steffen
Bedner, Kristine
Wright, Iain A.
Martin, Colin J.
Constable, Edwin C.
Fanget, Axel
Schonenberger, Christian
Calame, Michel
Keywords: Chemical sensing
Nanoribbons
Sodium
Fluoride
Gold
Ion-sensitive field-effect transistors
ChemFETs
Issue Date: 2016
Publisher: © The Authors. Published by MDPI AG
Citation: STOOP, R.L. ... et al., 2016. Implementing silicon nanoribbon field-effect transistors as arrays for multiple ion detection. Biosensors, 6(2): 21
Abstract: © 2016 by the author.Ionic gradients play a crucial role in the physiology of the human body, ranging from metabolism in cells to muscle contractions or brain activities. To monitor these ions, inexpensive, label-free chemical sensing devices are needed. Field-effect transistors (FETs) based on silicon (Si) nanowires or nanoribbons (NRs) have a great potential as future biochemical sensors as they allow for the integration in microscopic devices at low production costs. Integrating NRs in dense arrays on a single chip expands the field of applications to implantable electrodes or multifunctional chemical sensing platforms. Ideally, such a platform is capable of detecting numerous species in a complex analyte. Here, we demonstrate the basis for simultaneous sodium and fluoride ion detection with a single sensor chip consisting of arrays of gold-coated SiNR FETs. A microfluidic system with individual channels allows modifying the NR surfaces with self-assembled monolayers of two types of ion receptors sensitive to sodium and fluoride ions. The functionalization procedure results in a differential setup having active fluoride- and sodium-sensitive NRs together with bare gold control NRs on the same chip. Comparing functionalized NRs with control NRs allows the compensation of non-specific contributions from changes in the background electrolyte concentration and reveals the response to the targeted species.
Description: This is an Open Access Article. It is published by MDPI AG under the Creative Commons Attribution 4.0 Unported Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/
Sponsor: This work was supported by the Swiss Nano-Tera program, the European Commission under the FP7-NMP (Nanosciences, Nanotechnologies, Materials and new Production Technologies) project Hysens (263091), FP7-ICT (Information and Communication Technologies) project SYMONE (105244) and H2020 FET Open project RECORD-IT (664786) and the Swiss National Science Foundation as part of the National Centres of Competence in Research (NCCR) Molecular Systems Engineering.
Version: Published
DOI: 10.3390/bios6020021
URI: https://dspace.lboro.ac.uk/2134/23512
Publisher Link: http://dx.doi.org/10.3390/bios6020021
ISSN: 0265-928X
Appears in Collections:Published Articles (Chemistry)

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