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Title: Job strain as a risk factor for clinical depression: systematic review and meta-analysis with additional individual participant data
Authors: Madsen, Ida E.H.
Nyberg, Solja T.
Magnusson Hanson, Linda L.
Ferrie, Jane E.
Ahola, Kirsi
Alfredsson, Lars
Batty, G. David
Bjorner, Jakob B.
Borritz, Marianne
Burr, Hermann
Chastang, Jean-François
de Graaf, Ron
Dragano, Nico
Hamer, Mark
Jokela, Markus
Knutsson, Anders
Koskenvuo, Markku
Koskinen, Aki
Leineweber, Constanze
Niedhammer, Isabelle
Nielsen, Martin L.
Nordin, Maria
Oksanen, Tuula
Pejtersen, Jan H.
Pentti, Jaana
Plaisier, Inger
Salo, Paula
Singh-Manoux, Archana
Suominen, Sakari
Theorell, Tores
Toppinen-Tanner, Salla
Vahtera, Jussi
Vaananen, Ari
Kivimaki, Mika
Westerholm, Peter J.M.
Westerlund, Hugo
Fransson, Eleonor I.
Heikkila, Katriina
Virtanen, Marianna
Rugulies, Reiner
Kivimaki, Mika
Issue Date: 2017
Publisher: © Cambridge University Press
Citation: MADSEN, I.E.H. ... et al, 2017. Job strain as a risk factor for clinical depression: systematic review and meta-analysis with additional individual participant data. Psychological Medicine, 47 (8), pp. 1342-1356.
Abstract: Background Adverse psychosocial working environments characterized by job strain (the combination of high demands and low control at work) are associated with an increased risk of depressive symptoms among employees, but evidence on clinically diagnosed depression is scarce. We examined job strain as a risk factor for clinical depression. Methods We identified published cohort studies from a systematic literature search in PubMed and PsycNET and obtained 14 cohort studies with unpublished individuallevel data from the Individual-Participant-Data Meta-analysis in Working Populations (IPD-Work) consortium. Summary estimates of the association were obtained using random effects models. Individual-level data analyses were based on a pre-published study protocol (F1000Res 2013;2:233). Results We included 6 published studies with a total of 27 461 individuals and 914 incident cases of clinical depression. From unpublished datasets we included 120 221 individuals and 982 first episodes of hospital-treated clinical depression. Job strain was associated with an increased risk of clinical depression in both published (Relative Risk [RR]= 1.77, 95% confidence interval [CI] 1.47-2.13) and unpublished datasets (RR=1.27, 95% CI 1.04-1.55). Further individual participant analyses showed a similar association across sociodemographic subgroups and after excluding individuals with baseline somatic disease. The association was unchanged when excluding individuals with baseline depressive symptoms (RR=1.25, 95% CI: 0.94-1.65), but attenuated on adjustment for a continuous depressive symptoms score (RR=1.03, 95% CI: 0.81- 1.32). Conclusion Job strain may precipitate clinical depression among employees. Future intervention studies.
Description: This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Version: Published
DOI: 10.1017/S003329171600355X
URI: https://dspace.lboro.ac.uk/2134/23541
Publisher Link: http://dx.doi.org/10.1017/S003329171600355X
ISSN: 1469-8978
Appears in Collections:Published Articles (Sport, Exercise and Health Sciences)

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