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Title: Association of serum lipids and coronary artery disease with polymorphisms in the Apolipoprotein AI-CIII-AIV gene cluster
Authors: Rai, Himanshu
Sinha, Nakul
Finn, James
Agrawal, Suraksha
Mastana, Sarabjit S.
Keywords: Apolipoprotein (Apo) AI-CIII-AIV gene cluster
Single nucleotide polymorphisms (SNPs)
Serum lipids
Coronary artery disease (CAD)
Linkage disequilibrium
Issue Date: 2016
Publisher: © The Authors. Published by Cogent Medicine
Citation: RAI, H. ...et al., 2016. Association of serum lipids and coronary artery disease with polymorphisms in the Apolipoprotein AI-CIII-AIV gene cluster. Cogent Medicine, 3: 1266789.
Abstract: Genetic variants are considered as one of the main determinants of the concentration of serum lipids and coronary artery disease (CAD). Polymorphisms in the Apolipoprotein (Apo) AI-CIII-AIV gene cluster has been known to affect the concentrations of various lipid sub-fractions and the risk of CAD. The present study assessed associations between polymorphisms of the Apo AI-CIII-AIV gene cluster, [ApoA-I,-75G > A, (rs1799837); ApoC-III 3238C > G, (SstI), (rs5128) and ApoA-IV, Thr347Ser(347A > T), (rs675)] with serum lipids and their contributions to CAD in North Indian population. We recruited age, sex matched, 200 CAD patients and 200 healthy controls and tested them for fasting levels of serum lipids. We genotyped selected polymorphisms using polymerase chain reaction-restriction fragment length polymorphism. There were no statistically significant association of selected polymorphisms (or their combinations) with CAD even after employing additive, dominant and recessive models. However there was significant association of selected polymorphisms with various lipid traits amongst the control cohort (p < 0.05). Mean levels of high density lipoprotein cholesterol and triglycerides were found to be significantly higher among controls carrying at least one mutant allele at ApoA1- 75G > A (p = 0.019) and ApoCIII SstI (p < 0.001) polymorphism respectively. Our study observed that the selected polymorphisms in the ApoAI-CIII-AIV gene cluster although significantly affect various lipid traits but this affect does not seem to translate into association with CAD, at least among North Indian population.
Description: This is an Open Access Article. It is published by Cogent Medicine under the Creative Commons Attribution 4.0 Unported Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/
Version: Published
DOI: 10.1080/2331205X.2016.1266789
URI: https://dspace.lboro.ac.uk/2134/23581
Publisher Link: http://dx.doi.org/10.1080/2331205X.2016.1266789
Appears in Collections:Published Articles (Sport, Exercise and Health Sciences)

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