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|Title: ||Association of serum lipids and coronary artery disease with polymorphisms in the Apolipoprotein AI-CIII-AIV gene cluster|
|Authors: ||Rai, Himanshu|
Mastana, Sarabjit S.
|Keywords: ||Apolipoprotein (Apo) AI-CIII-AIV gene cluster|
Single nucleotide polymorphisms (SNPs)
Coronary artery disease (CAD)
|Issue Date: ||2016|
|Publisher: ||© The Authors. Published by Cogent Medicine|
|Citation: ||RAI, H. ...et al., 2016. Association of serum lipids and coronary artery disease with polymorphisms in the Apolipoprotein AI-CIII-AIV gene cluster. Cogent Medicine, 3: 1266789.|
|Abstract: ||Genetic variants are considered as one of the main determinants of the concentration of serum lipids and coronary artery disease (CAD). Polymorphisms in the Apolipoprotein (Apo) AI-CIII-AIV gene cluster has been known to affect the concentrations of various lipid sub-fractions and the risk of CAD. The present study assessed associations between polymorphisms of the Apo AI-CIII-AIV gene cluster, [ApoA-I,-75G > A, (rs1799837); ApoC-III 3238C > G, (SstI), (rs5128) and ApoA-IV, Thr347Ser(347A > T), (rs675)] with serum lipids and their contributions to CAD in North Indian population. We recruited age, sex matched, 200 CAD patients and 200
healthy controls and tested them for fasting levels of serum lipids. We genotyped selected polymorphisms using polymerase chain reaction-restriction fragment length polymorphism. There were no statistically significant association of selected
polymorphisms (or their combinations) with CAD even after employing additive, dominant and recessive models. However there was significant association of selected
polymorphisms with various lipid traits amongst the control cohort (p < 0.05).
Mean levels of high density lipoprotein cholesterol and triglycerides were found to
be significantly higher among controls carrying at least one mutant allele at ApoA1-
75G > A (p = 0.019) and ApoCIII SstI (p < 0.001) polymorphism respectively. Our study observed that the selected polymorphisms in the ApoAI-CIII-AIV gene cluster although significantly affect various lipid traits but this affect does not seem to translate into association with CAD, at least among North Indian population.|
|Description: ||This is an Open Access Article. It is published by Cogent Medicine under the Creative Commons Attribution 4.0 Unported Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/|
|Publisher Link: ||http://dx.doi.org/10.1080/2331205X.2016.1266789|
|Appears in Collections:||Published Articles (Sport, Exercise and Health Sciences)|
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