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|Title: ||ESHRE guideline: management of women with premature ovarian insufficiency|
|Authors: ||Webber, L.|
|Keywords: ||Premature ovarian insufficiency|
European Society of Human Reproduction and Embryology
|Issue Date: ||2016|
|Publisher: ||© The Author 2016. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology|
|Citation: ||WEBBER, L. ... et al., 2016. ESHRE guideline: management of women with premature ovarian insufficiency. Human Reproduction, 31 (5), pp. 926 - 937.|
|Abstract: ||study question: What is the optimal management of women with premature ovarian insufficiency (POI) based on the best available
evidence in the literature?
summary answer: The guideline development group (GDG) formulated 99 recommendations answering 31 key questions on the
diagnosis and treatment of women with POI.
what is known already: NA.
study design, size, duration: This guideline was produced by a multidisciplinary group of experts in the field using the methodology
of the Manual for ESHRE Guideline Development, including a thorough systematic search of the literature, quality assessment of the included
papers up to September 2014 and consensus within the guideline group on all recommendations. The GDG included a patient representative
to ensure input from women with POI. After finalization of the draft, the European Society for Human Reproduction and Embryology
(ESHRE) members and professional organizations were asked to review the guideline.
participants/materials, setting, methods: NA.
main results and the role of chance: The guideline provides 17 recommendations on diagnosis and assessment of POI and 46
recommendations on the different sequelae of POI and their consequences for monitoring and treatment. Furthermore, 24 recommendations
were formulated on hormone replacement therapy in women with POI, and two on alternative and complementary treatment. A chapter on
puberty induction resulted in five recommendations.
limitations, reasons for caution: The main limitation of the guideline is that, due to the lack of data, many of the recommendations
are based on expert opinion or indirect evidence from studies on post-menopausal women or women with Turner Syndrome.
wider implications of the findings: Despite the limitations, the guideline group is confident that this document will be able to
guide health care professionals in providing the best practice for managing women with POI given current evidence. Furthermore, the guideline
grouphas formulated research recommendations on the gaps in knowledge identified in the literature searches, in an attempt to stimulate research
on the key issues in POI.|
|Description: ||This article was published in the journal, Human Reproduction [© The Author 2014. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology] and the definitive version is available at: http://dx.doi.org/:10.1093/humrep/dew027|
|Sponsor: ||The guideline was developed and funded by ESHRE, covering expenses associated with the guideline meetings, with the literature searches and with the implementation of the guideline.|
|Version: ||Accepted for publication|
|Publisher Link: ||http://dx.doi.org/10.1093/humrep/dew027|
|Appears in Collections:||Published Articles (Sport, Exercise and Health Sciences)|
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