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Title: Nutrition for the ageing brain: towards evidence for an optimal diet
Authors: Vauzour, David
Camprubi-Robles, Maria
Miquel-Kergoat, Sophie
Andres-Lacueva, Cristina
Banati, Diana
Barberger-Gateau, Pascale
Bowman, Gene L.
Caberlotto, Laura
Clarke, Robert
Hogervorst, Eef
Kiliaan, Amanda J.
Lucca, Ugo
Manach, Claudine
Minihane, Anne-Marie
Mitchell, Ellen S.
Perneczky, Robert
Perry, V. Hugh
Roussel, Anne-Marie
Schuermans, Jeroen
Sijben, John
Spencer, Jeremy P.E.
Thuret, Sandrine
van de Rest, Ondine
Vandewoude, Maurits
Wesnes, Keith
Williams, Robert J.
Williams, Robin S.B.
Ramirez, Maria
Keywords: Cognition
Cognitive ageing
Cognitive decline
Preventive diet
Issue Date: 2017
Publisher: Elsevier (© the authors)
Citation: VAUZOUR, D. ... et al., 2017. Nutrition for the ageing brain: towards evidence for an optimal diet. Ageing Research Reviews, 35, pp. 222–240.
Abstract: As people age they become increasingly susceptible to chronic and extremely debilitating brain diseases. The precise cause of the neuronal degeneration underlying these disorders, and indeed normal brain ageing remains however elusive. Considering the limits of existing preventive methods, there is a desire to develop effective and safe strategies. Growing preclinical and clinical research in healthy individuals or at the early stage of cognitive decline has demonstrated the beneficial impact of nutrition on cognitive functions. The present review is the most recent in a series produced by the Nutrition and Mental Performance Task Force under the auspice of the International Life Sciences Institute Europe (ILSI Europe). The latest scientific advances specific to how dietary nutrients and non-nutrient may affect cognitive ageing are presented. Furthermore, several key points related to mechanisms contributing to brain ageing, pathological conditions affecting brain function, and brain biomarkers are also discussed. Overall, findings are inconsistent and fragmented and more research is warranted to determine the underlying mechanisms and to establish dose-response relationships for optimal brain maintenance in different population subgroups. Such approaches are likely to provide the necessary evidence to develop research portfolios that will inform about new dietary recommendations on how to prevent cognitive decline.
Description: This is an open access article published by Elsevier under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4. 0/).
Sponsor: The workshop ‘Nutrition for the Ageing Brain: Towards Evidence of an Optimal Diet’ was organized with funds from the ILSI Europe Nutrition and Mental Performance Task Force.
Version: Published
DOI: 10.1016/j.arr.2016.09.010
URI: https://dspace.lboro.ac.uk/2134/23609
Publisher Link: http://dx.doi.org/10.1016/j.arr.2016.09.010
ISSN: 1872-9649
Appears in Collections:Published Articles (Sport, Exercise and Health Sciences)

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