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Title: Terminal sterilization: Conventional methods versus emerging cold atmospheric pressure plasma technology for non‐viable biological tissues
Authors: Marsit, Nagi M.
Sidney, Laura E.
Branch, Matthew J.
Wilson, Samantha L.
Hopkinson, Andrew
Keywords: Cold plasma
Dielectric barrier discharge
Plasma treatment
Sterilization
Tissue engineering
Issue Date: 2017
Publisher: © Wiley-VCH Verlag
Citation: MARSIT, N.M. ...et al., 2017. Terminal sterilization: Conventional methods versus emerging cold atmospheric pressure plasma technology for non‐viable biological tissues. Plasma Processes and Polymers, 14 (7), e1600134.
Abstract: Tissue products are susceptible to microbial contamination from different sources, which may cause disease transmission upon transplantation. Terminal sterilization using gamma radiation, electron-beam, and ethylene oxide protocols are well established and accepted, however, such methods have known disadvantages associated with compromised tissue integrity, functionality, safety, complex logistics, availability, and cost. Non-thermal (cold) atmospheric pressure plasma (CAP) is an emerging technology that has several biomedical applications including sterilization of tissues, and the potential to surpass current terminal sterilization techniques. This review discusses the limitations of conventional terminal sterilization technologies for biological materials, and highlights the benefits of utilizing CAP.
Description: This paper is in closed access until 15th Dec 2017.
Sponsor: Funding from The Authority for Research, Science, and Technology of the Ministry of Higher Education and Scientific Research-Libya (Scholarship 404/2013) is gratefully acknowledged.
Version: Accepted
DOI: 10.1002/ppap.201600134
URI: https://dspace.lboro.ac.uk/2134/23656
Publisher Link: http://dx.doi.org/10.1002/ppap.201600134
ISSN: 1612-8869
Appears in Collections:Closed Access (Mechanical, Electrical and Manufacturing Engineering)

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