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Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/23956

Title: Ultrasonically assisted cutting of bio-tissues in microtomy
Authors: Wang, Dong
Roy, Anish
Silberschmidt, Vadim V.
Keywords: Ultrasonically assisted cutting
Power ultrasonics
Microtome
Experimental study
Surface roughness
Issue Date: 2016
Publisher: © Elsevier
Citation: WANG, D., ROY, A. and SILBERSCHMIDT, V.V., 2016. Ultrasonically assisted cutting of bio-tissues in microtomy. Physics Procedia, 87, pp. 118-124.
Abstract: Modern-day histology of bio-tissues for supporting stratified medicine diagnoses requires high-precision cutting to ensure high quality extremely thin specimens used in analysis. Additionally, the cutting quality is significantly affected by a wide variety of soft and hard tissues in the samples. This paper deals with development of a next generation of microtome employing introduction of controlled ultrasonic vibration to realise a hybrid cutting process of bio-tissues. The study is based on a combination of advanced experimental and numerical (finite-element) studies of multi-body dynamics of a cutting system. The quality of cut samples produced with the prototype is compared with the state-of-the-art.
Description: This is an Open Access article published under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/). This conference paper was delivered at the 44th Annual Symposium of the Ultrasonic Industry Association (UIA), Washington, DC, USA, 20th-22nd April 2015.
Sponsor: The authors wish to acknowledge the Innovate UK for its funding and are very grateful to Cellpath Ltd. UK for its support.
Version: Published
DOI: 10.1016/j.phpro.2016.12.018
URI: https://dspace.lboro.ac.uk/2134/23956
Publisher Link: http://dx.doi.org/10.1016/j.phpro.2016.12.018
ISSN: 1875-3892
Appears in Collections:Published Articles (Mechanical, Electrical and Manufacturing Engineering)

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