Please use this identifier to cite or link to this item:
|Title: ||Isolation of novel para-pentyl phenyl benzoate from Mondia whitei. (Hook.F) Skeels (Periplocaceae), its structure, synthesis, and neuropharamacological evaluation|
|Authors: ||Taiwo, Bamigboye J.|
Osasan, Josephine Y.
Olubiyi, Olujide O.
Oyemitan, Idris A.
Atoyebi, Shakir A.
Elsegood, Mark R.J.
Jones, Raymond C.F.
|Keywords: ||Mondia whitei|
Isolation and synthesis
Sedative and anxiolytic effect
Para pentylphenyl benzoate
|Issue Date: ||2017|
|Publisher: ||African Traditional Herbal Medicine Supporters Initiative (ATHMSI)|
|Citation: ||TAIWO, B.J. ... et al, 2017. Isolation of novel para-pentyl phenyl benzoate from Mondia whitei. (Hook.F) Skeels (Periplocaceae), its structure, synthesis, and neuropharamacological evaluation. African Journal of Traditional, Complementary and Alternative Medicines, 14 (1), pp. 219-230.|
|Abstract: ||Background: Mondia whitei L. (Hook. F.) Skeels (Periplocaceae) is a medicinal plant used locally in managing pain, fever, loss of appetite and as aphrodiasc in the South-Western states of Nigeria. However, the fruit is consumed habitually in the South-Eastern states of Nigeria, leading to speculation that it may possess some central nervous system effect but which has
not been scientifically investigated, hence this study.
Methodology: Fresh fruits of Mondia whitei were collected and identified by a taxonomist. They were chopped into small
pieces and extracted with absolute ethanol. The crude extract was subjected to various chromatographic techniques to isolate a novel compound whose structure was elucidated from the analysis of the crystal data and by extensive use of spectroscopy. The structure was confirmed by synthesis. The compound was subjected to anxiolytic and sedative activity
assay. Computational analysis of the receptor binding event of isolated compound at the gamma amino butyric acid A receptor was also evaluated.
Results: The structure of the compound was elucidated as para pentyl phenyl benzoate. The neuropharmacological
evaluation of the compound indicated significant (p<0.05) depression of the central nervous system. The binding
characteristics of the compound to gamma amino butyric acid A receptors appears to be more favorable than those obtained
for gamma amino butyric acid, chlorpromazine, benzamidine, and is comparable with the affinity obtained for pentobarbitone and diazepam.
Conclusion These present data provide evidence for the role of para pentyl phenyl benzoate in the habitual consumption of
the fruit as well as its central nervous system activities.|
|Description: ||This is an Open Access article. It is published under the Creative Commons Attribution 4.0 Unported Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/|
|Sponsor: ||We wish to thank the Commonwealth Scholarship Commission (CSC), United Kingdom for a fellowship award (NGCF-2012-160) to TBJ. We also wish to acknowledge the use of the EPSRC's Chemical Database Service hosted by the RSC.|
|Publisher Link: ||http://dx.doi.org/10.21010/ajtcam.v14i1.4522|
|Appears in Collections:||Published Articles (Chemistry)|
Files associated with this item:
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.