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Title: Scalable synthesis of multicolour conjugated polymer nanoparticles via Suzuki-Miyaura polymerisation in a miniemulsion and application in bioimaging
Authors: Behrendt, Jonathan M.
Esquivel Guzman, Jair A.
Purdie, Laura
Willcock, Helen
Morrison, John J.
Foster, Andrew B.
O'Reilly, Rachel K.
McCairn, Mark C.
Turner, Michael L.
Keywords: Conjugated polymer nanoparticles
Bioimaging
Scalable
Miniemulsion
Suzuki-Miyaura polymerisation
Issue Date: 2016
Publisher: © Elsevier B.V.
Citation: BEHRENDT, J. M. ... et al., 2016. Scalable synthesis of multicolour conjugated polymer nanoparticles via Suzuki-Miyaura polymerisation in a miniemulsion and application in bioimaging. Reactive and Functional Polymers, 107 (October), pp. 69 - 77
Abstract: Suzuki cross-coupling polymerisation of aryldibromides and aryldiboronate esters in a sodium dodecyl sulfate (SDS)-stabilised miniemulsion provides a versatile and direct route to fluorescent conjugated polymer nanoparticles (CPNs). These nanoparticles have a conjugated backbone based on poly(9,9-dioctylfluorene) (PFO), however, significant structural diversity is introduced by incorporation of electron withdrawing, heterocyclic comonomers (5–50 mol.%) in order to tune the emission wavelengths from blue to far-red/near-infrared. The robust nature of the polymerisation methodology allows for rapid assessment of the relationship between polymer composition, chain morphology and optical properties of the resultant CPNs. Moreover, the CPNs (after a simple and rapid purification step) can be used directly in fluorescence-based intracellular labelling experiments (in HCT116 cells), in which they display low cytotoxicity at biologically-useful concentrations.
Description: Closed access until 1 March 2018. This article was published in the journal Reactive and Functional Polymers [© Elsevier B.V.] and the definitive version is available at: http://dx.doi.org/10.1016/j.reactfunctpolym.2016.08.006
Sponsor: The authors thank the University of Manchester Intellectual Property for award of Proof of Principle funding and the Engineering and Physical Sciences Research Council (grant number EP/K039547/1). A.B.F. would like to acknowledge funding from the Knowledge Centre for Materials Chemistry (KCMC). J.A.E.G. acknowledges Conacyt for award of a PhD scholarship.
Version: Accepted for publication
DOI: 10.1016/j.reactfunctpolym.2016.08.006
URI: https://dspace.lboro.ac.uk/2134/24042
Publisher Link: http://dx.doi.org/10.1016/j.reactfunctpolym.2016.08.006
ISSN: 1381-5148
Appears in Collections:Closed Access (Materials)

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