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|Title: ||Scalable synthesis of multicolour conjugated polymer nanoparticles via Suzuki-Miyaura polymerisation in a miniemulsion and application in bioimaging|
|Authors: ||Behrendt, Jonathan M.|
Esquivel Guzman, Jair A.
Morrison, John J.
Foster, Andrew B.
O'Reilly, Rachel K.
McCairn, Mark C.
Turner, Michael L.
|Keywords: ||Conjugated polymer nanoparticles|
|Issue Date: ||2016|
|Publisher: ||© Elsevier B.V.|
|Citation: ||BEHRENDT, J. M. ... et al., 2016. Scalable synthesis of multicolour conjugated polymer nanoparticles via Suzuki-Miyaura polymerisation in a miniemulsion and application in bioimaging. Reactive and Functional Polymers, 107 (October), pp. 69 - 77|
|Abstract: ||Suzuki cross-coupling polymerisation of aryldibromides and aryldiboronate esters in a sodium dodecyl sulfate (SDS)-stabilised miniemulsion provides a versatile and direct route to fluorescent conjugated polymer nanoparticles (CPNs). These nanoparticles have a conjugated backbone based on poly(9,9-dioctylfluorene) (PFO), however, significant structural diversity is introduced by incorporation of electron withdrawing, heterocyclic comonomers (5–50 mol.%) in order to tune the emission wavelengths from blue to far-red/near-infrared. The robust nature of the polymerisation methodology allows for rapid assessment of the relationship between polymer composition, chain morphology and optical properties of the resultant CPNs. Moreover, the CPNs (after a simple and rapid purification step) can be used directly in fluorescence-based intracellular labelling experiments (in HCT116 cells), in which they display low cytotoxicity at biologically-useful concentrations.|
|Description: ||Closed access until 1 March 2018. This article was published in the journal Reactive and Functional Polymers [© Elsevier B.V.] and the definitive version is available at: http://dx.doi.org/10.1016/j.reactfunctpolym.2016.08.006|
|Sponsor: ||The authors thank the University of Manchester Intellectual Property
for award of Proof of Principle funding and the Engineering and Physical
Sciences Research Council (grant number EP/K039547/1). A.B.F.
would like to acknowledge funding from the Knowledge Centre for
Materials Chemistry (KCMC). J.A.E.G. acknowledges Conacyt for award
of a PhD scholarship.|
|Version: ||Accepted for publication|
|Publisher Link: ||http://dx.doi.org/10.1016/j.reactfunctpolym.2016.08.006|
|Appears in Collections:||Closed Access (Materials)|
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