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Title: Acute exercise and appetite-regulating hormones in overweight and obese individuals: A meta-analysis
Authors: Douglas, Jessica A.
Deighton, Kevin
Atkinson, Jan Maria
Sari-Sarraf, Vahid
Stensel, David J.
Atkinson, Greg
Issue Date: 2016
Publisher: © The Authors. Published by the Hindawi Publishing Corporation
Citation: DOUGLAS, J.A. ...et al., 2016. Acute exercise and appetite-regulating hormones in overweight and obese individuals: A meta-analysis. Journal of Obesity, 2016: 2643625.
Abstract: In lean individuals, acute aerobic exercise is reported to transiently suppress sensations of appetite, suppress blood concentrations of acylated ghrelin (AG), and increase glucagon-like peptide-1 (GLP-1) and peptide-YY (PYY). Findings in overweight/obese individuals have yet to be synthesised. In this systematic review and meta-analysis, we quantified the effects that acute exercise has on AG and total PYY and GLP-1 in overweight/obese individuals. The potential for body mass index (BMI) to act as a moderator for AG was also explored. Six published studies (73 participants, 78% male, mean BMI: 30.6 kg·m-2) met the inclusion criteria. Standardised mean differences (SMDs) and standard errors were extracted for AG and total PYY and GLP-1 concentrations in control and exercise trials and synthesised using a random effects meta-analysis model. BMI was the predictor in metaregression for AG. Exercise moderately suppressed AG area-under-the-curve concentrations (pooled SMD:-0.34, 95% CI:-0.53 to-0.15). The magnitude of this reduction was greater for higher mean BMIs (pooled metaregression slope:-0.04 SMD/kg·m-2 (95% CI:-0.07 to 0.00)). Trivial SMDs were obtained for total PYY (0.10, 95% CI:-0.13 to 0.31) and GLP-1 (-0.03, 95% CI:-0.18 to 0.13). This indicates that exercise in overweight/obese individuals moderately alters AG in a direction that could be associated with decreased hunger and energy intake. This trial is registered with PROSPERO: CRD42014006265.
Description: This is an Open Access Article. It is published by Hindawi under the Creative Commons Attribution 4.0 Unported Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/
Sponsor: The research was supported by the National Institute for Health Research (NIHR) Diet, Lifestyle & Physical Activity Biomedical Research Unit based at the University Hospitals of Leicester and Loughborough University.
Version: Published
DOI: 10.1155/2016/2643625
URI: https://dspace.lboro.ac.uk/2134/24095
Publisher Link: http://dx.doi.org/10.1155/2016/2643625
ISSN: 2090-0708
Appears in Collections:Published Articles (Sport, Exercise and Health Sciences)

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