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Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/24163

Title: 3D printed fluidics with embedded analytic functionality for automated reaction optimisation
Authors: Capel, Andrew J.
Wright, Andrew
Harding, Matthew
Weaver, George W.
Li, Yuqi
Harris, Russell A.
Edmondson, Steve
Goodridge, Ruth
Christie, Steven D.R.
Keywords: 3D printing
Inline reaction analysis
Reaction optimisation
Selective laser melting
Stereolithography
Issue Date: 2017
Publisher: © Capel et al. Published by the Beilstein-Institut
Citation: CAPEL, A.J. ... et al, 2017. 3D printed fluidics with embedded analytic functionality for automated reaction optimisation. Beilstein Journal of Organic Chemistry, 13, pp. 111-119.
Abstract: Additive manufacturing or ‘3D printing’ is being developed as a novel manufacturing process for the production of bespoke micro- and milliscale fluidic devices. When coupled with online monitoring and optimisation software, this offers an advanced, customised method for performing automated chemical synthesis. This paper reports the use of two additive manufacturing processes, stereolithography and selective laser melting, to create multifunctional fluidic devices with embedded reaction monitoring capability. The selectively laser melted parts are the first published examples of multifunctional 3D printed metal fluidic devices. These devices allow high temperature and pressure chemistry to be performed in solvent systems destructive to the majority of devices manufactured via stereolithography, polymer jetting and fused deposition modelling processes previously utilised for this application. These devices were integrated with commercially available flow chemistry, chromatographic and spectroscopic analysis equipment, allowing automated online and inline optimisation of the reaction medium. This set-up allowed the optimisation of two reactions, a ketone functional group interconversion and a fused polycyclic heterocycle formation, via spectroscopic and chromatographic analysis.
Description: This is an Open Access Article. It is published by the Beilstein-Institut under the Creative Commons Attribution 4.0 Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/
Sponsor: Loughborough University Materials Research School and EPSRC.
Version: Published
DOI: 10.3762/bjoc.13.14
URI: https://dspace.lboro.ac.uk/2134/24163
Publisher Link: http://dx.doi.org/10.3762/bjoc.13.14
Appears in Collections:Published Articles (Sport, Exercise and Health Sciences)

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