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Title: Rapid analysis of N-methylpyrrolidine in cefepime with thermal desorption ion mobility spectrometry
Authors: Reynolds, James C.
Giddings, Laura
Usen, Ime C.
Cheng, Haodong
Shan, Junmin
Turner, Matthew A.
Creaser, Colin S.
Keywords: Ion mobility
Pharmaceutical impurities
Direct analysis
Thermal desorption
HPLC
Issue Date: 2016
Publisher: © Springer
Citation: REYNOLDS, J.C. ... et al, 2016. Rapid analysis of N-methylpyrrolidine in cefepime with thermal desorption ion mobility spectrometry. International Journal for Ion Mobility Spectrometry, 19 (4), pp. 209-217.
Abstract: N-methyl-pyrrolidine (NMP) a potential impurity in the cephalosporin antibiotic cefepime is analysed using a rapid thermal desorption – ion mobility spectrometry (TD-IMS) method. The thermal desorption approach is shown to be capable of rapidly extracting NMP from the cefepime at 80 °C without causing thermal degradation of the cefepime. The ion mobility method has an analysis time of 1 min and demonstrates good linearity over a range from 0.3–3.0 μg ml−1 of NMP, with limits of detection and quantification of 0.056 and 0.1875 μg ml−1 respectively. The developed method was applied to the analysis of a cefepime sample and determined that NMP was present in a cefepime sample at a level of 0.0376 % with a percentage relative standard deviation (n = 6) of 3.2 %. This was compared with a LC-UV method which was in close agreement measuring NMP at 0.0384 % in the cefepime sample with a percentage RSD (n = 6) of 5.7 %. These results show that the TD-IMS method gives comparable data to the established LC methods and demonstrates the potential of TD-IMS for rapid measurement of volatile compounds in pharmaceutical matrices.
Description: This paper is closed access until 8th November 2017.
Version: Accepted for publication
DOI: 10.1007/s12127-016-0210-7
URI: https://dspace.lboro.ac.uk/2134/24347
Publisher Link: http://dx.doi.org/10.1007/s12127-016-0210-7
ISSN: 1435-6163
Appears in Collections:Closed Access (Chemistry)

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