Loughborough University
Leicestershire, UK
LE11 3TU
+44 (0)1509 263171
Loughborough University

Loughborough University Institutional Repository

Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/24375

Title: Regular exercise during haemodialysis promotes an anti-inflammatory leukocyte profile
Authors: Dungey, Maurice
Young, Hannah M.L.
Churchward, Darren R.
Burton, James O.
Smith, Alice C.
Bishop, Nicolette
Keywords: Cytokines
Issue Date: 2017
Publisher: Oxford University Press
Citation: DUNGEY, M. ... et al, 2017. Regular exercise during haemodialysis promotes an anti-inflammatory leukocyte profile. Clinical Kidney Journal, doi:10.1093/ckj/sfx015.
Abstract: Background Cardiovascular disease (CVD) is the most common cause of mortality in haemodialysis (HD) patients and is highly predicted by markers of chronic inflammation. Regular exercise may have beneficial anti-inflammatory effects, but this is unclear in HD patients. This study assessed the effect of regular intradialytic exercise on soluble inflammatory factors and inflammatory leukocyte phenotypes. Methods Twenty-two HD patients from a centre where intradialytic cycling was offered thrice-weekly and 16 HD patients receiving usual care volunteered. Exercising patients aimed to cycle for 30 min at RPE of “somewhat hard”. Baseline characteristic were compared with 16 healthy age-matched individuals. Physical function, soluble inflammatory markers and leukocyte phenotypes were assessed again after 6 months of regular exercise. Results Patients were less active than their healthy counterparts and had significant elevations in measures of inflammation (IL-6, CRP, TNF-α, intermediate and non-classical monocytes; all P<0.001). Six months of regular intradialytic exercise improved physical function (sit-to-stand 60). After 6 months the proportion of intermediate monocytes in the exercising patients reduced compared to non-exercisers (7.58±1.68 to 6.38±1.81% vs. 6.86±1.45 to 7.88±1.66%; P<0.01). Numbers (but not proportion) of regulatory T cells decreased in the non-exercising patients only (P<0.05). Training had no significant effect on circulating IL-6, CRP or TNF-α concentrations. Conclusions These findings suggest regular intradialytic exercise is associated with an anti-inflammatory effect at a circulating cellular level but not in circulating cytokines. This may be protective against the increased risk of CVD and mortality that is associated with chronic inflammation and elevated numbers of intermediate monocytes.
Description: This paper is closed access until it is published.
Sponsor: The work was generously funded by the Stoneygate Trust and the Leicester Kidney Care Appeal, and supported by the National Institute for Health Research (NIHR) Diet, Lifestyle & Physical Activity Biomedical Research Unit based at University Hospitals of Leicester and Loughborough University.
Version: Accepted for publication
DOI: 10.1093/ckj/sfx015
URI: https://dspace.lboro.ac.uk/2134/24375
Publisher Link: http://dx.doi.org/10.1093/ckj/sfx015
ISSN: 2048-8505
Appears in Collections:Closed Access (Sport, Exercise and Health Sciences)

Files associated with this item:

File Description SizeFormat
Dungey et al. CKJ (LTHD study) Final accepted version 160217.pdfAccepted version569.28 kBAdobe PDFView/Open


SFX Query

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.