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Title: Distribution of APOE variants in four Northeast Indian populations
Authors: Santiago-Colon, Albeliz
Karns, Rebekah
Mastana, Sarabjit S.
Deka, Karns Ranjan
Keywords: Apolipoproteins E
Apolipoprotein E2
Apolipoprotein E3
Apolipoprotein E4
Single nucleotide polymorphism
Northeast India
Population genetics
Issue Date: 2017
Publisher: Croatian Anthropological Society
Citation: SANTIAGO-COLON, A. ...et al., 2017. Distribution of APOE variants in four Northeast Indian population. Collegium Antropologicum, 40(4), pp. 285-289.
Abstract: Polymorphisms in the human apolipoprotein E gene (ApoE) have been extensively studied for associations with various complex diseases. Numerous population genetic studies have reported the distribution of ApoE alleles in global populations. In this study, we present new data on the distribution of ApoE polymorphisms among four Northeast Indian populations, namely, Kachari, Rabha, Ahom, and an Indo-European caste group. Allele frequencies, Hardy-Weinberg equilibrium, genotype and phenotype probabilities were based on the two SNPs, rs7412 and rs429358. Of the APOE genotypes, derived from rs429358 and rs7412 SNPs, 3/3 and 3/4 genotypes were the most frequent in all groups and only Rabha showed higher frequency of 2/3 genotype. The Kachari population showed the highest frequency of CT genotype for SNP rs429358 and the highest frequency of allele *E4 in the Indian subcontinent, which was much higher than other study populations of eastern India.
Description: This is an Open Access Article. It is published by Croatian Anthropological Society under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 Unported Licence (CC BY-NC-ND). Full details of this licence are available at: http://creativecommons.org/licenses/by-nc-nd/4.0/
Version: Published
URI: https://dspace.lboro.ac.uk/2134/24499
Publisher Link: http://www.collantropol.hr/antropo/article/view/1523
ISSN: 0350-6134
Appears in Collections:Published Articles (Sport, Exercise and Health Sciences)

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