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Title: Microfluidic production of multiple emulsions
Authors: Vladisavljevic, Goran T.
Al Nuumani, Ruqaya
Nabavi, Seyed Ali
Keywords: Microfluidics
Multiple emulsion
Janus drop
Core/shell drops
Flow focusing
Ternary drop
Issue Date: 2017
Publisher: © The Authors. Published by MDPI.
Citation: VLADISAVLJEVIC, G.T., AL NUUMANI, R. and NABAVI, S.A., 2017. Microfluidic production of multiple emulsions. Micromachines, 8 (3), 75.
Abstract: Microfluidic devices are promising tools for the production of monodispersed tuneable complex emulsions. This review highlights the advantages of microfluidics for the fabrication of emulsions and presents an overview of the microfluidic emulsification methods including two-step and single-step methods for the fabrication of high-order multiple emulsions (double, triple, quadruple and quintuple) and emulsions with multiple and/or multi-distinct inner cores. The microfluidic methods for the formation of multiple emulsion drops with ultra-thin middle phase, multi-compartment jets, and Janus and ternary drops composed of two or three distinct surface regions are also presented. Different configurations of microfluidic drop makers are covered, such as co-flow, T-junctions and flow focusing (both planar and three-dimensional (3D)). Furthermore, surface modifications of microfluidic channels and different modes of droplet generation are summarized. Non-confined microfluidic geometries used for buoyancy-driven drop generation and membrane integrated microfluidics are also discussed. The review includes parallelization and drop splitting strategies for scaling up microfluidic emulsification. The productivity of a single drop maker is typically <1 mL/h; thus, more than 1000 drop makers are needed to achieve commercially relevant droplet throughputs of >1 L/h, which requires combining drop makers into twodimensional (2D) and 3D assemblies fed from a single set of inlet ports through a network of distribution and collection channels.
Description: This is an Open Access Article. It is published by MDPI under the Creative Commons Attribution 4.0 Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/
Sponsor: Ruqaya Al Nuumani holds a scholarship from “the Government of the Sultanate of Oman”.
Version: Published
DOI: 10.3390/mi8030075
URI: https://dspace.lboro.ac.uk/2134/24501
Publisher Link: http://dx.doi.org/10.3390/mi8030075
ISSN: 2072-666X
Appears in Collections:Published Articles (Chemical Engineering)

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