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Title: Solubilization of phenols by multimolecular aggregates formed by low molecular weight hyperbranched polyglycidol
Authors: Olea, Andres F.
Acevedo, Betsabe
Ossandon, Luis
Worrall, David R.
Keywords: Hyperbranched polyglycidol
Multimolecular aggregates
Partition coefficients
p-Alkylphenols
Fluorescence probing
Issue Date: 2017
Publisher: © Elsevier
Citation: OLEA, A.F. ... et al, 2017. Solubilization of phenols by multimolecular aggregates formed by low molecular weight hyperbranched polyglycidol. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 526, pp.1-7.
Abstract: Hyperbranched polymers have been proposed as potential carriers or host compartments for controlled drug delivery. In this work the solubilization of alkylphenols into aggregates formed by hyperbranched polyglycidol HPG and its ester derivative has been studied. HPG17 was synthesized by ring-opening polymerization of glycidol, and then the ester HPG4-RBr13 has been obtained by reaction of hPG17 with 2-bromo isobutyryl bromide. The critical aggregate concentration CAC and micropolarity of aggregates were determined by using pyrene as fluorescence probe. CAC values obtained are 2.5mM and 0.25mM, for HPG17 and HPG4-RBr13, respectively. Our results indicate that the hydrophobic effect is larger for HPG4-RBr13, and that their aggregates are more hydrophobic, than for HPG17. In addition, their sizes and sizes distribution were determined by DLS.The partition of phenols between the micellar and aqueous phase was studied by using the pseudo-phase model, and the results show that the partition coefficients increases with increasing length of the side alkyl chain, and are larger for HPG4-RBr13 micelles than for HPG17 micelles.
Description: This paper is closed access until 16th February 2018.
Sponsor: This work was supported by FONDECYT Grant 1130742.
Version: Accepted for publication
DOI: 10.1016/j.colsurfa.2017.02.032
URI: https://dspace.lboro.ac.uk/2134/24523
Publisher Link: http://dx.doi.org/10.1016/j.colsurfa.2017.02.032
ISSN: 0927-7757
Appears in Collections:Closed Access (Chemistry)

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