Loughborough University
Leicestershire, UK
LE11 3TU
+44 (0)1509 263171
Loughborough University

Loughborough University Institutional Repository

Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/24669

Title: Effect of microneedles on transdermal permeation enhancement of amlodipine
Authors: Nalluri, Buchi N.
Uppuluri, Chandrateja
Devineni, Jyothirmayee
Nayak, Atul
Nair, Karthik J.
Whiteside, Benjamin R.
Das, Diganta Bhusan
Keywords: Amlodipine
Histological examination
Microneedle geometry
Scaling analyses
Transdermal permeation
Issue Date: 2017
Publisher: Springer © Controlled Release Society
Citation: NALLURI, B.N. ... et al, 2017. Effect of microneedles on transdermal permeation enhancement of amlodipine. Drug Delivery and Translational Research, 7 (3), pp. 383–394.
Abstract: The present study aimed to investigate the effect of microneedle (MN) geometry parameters like length, density, shape and type on transdermal permeation enhancement of amlodipine (AMLO). Two types of MN devices viz. AdminPatch® arrays (ADM) (0.6, 1.2 and 1.5 mm lengths) and laboratory-fabricated polymeric MNs (PM) of 0.6 mm length were employed. In the case of PMs, arrays were applied thrice at different places within a 1.77-cm2 skin area (PM-3) to maintain the MN density closer to 0.6 mm ADM. Scaling analyses were done using dimensionless parameters like concentration of AMLO (Ct/Cs), thickness (h/L) and surface area of the skin (Sa/L2). Microinjection moulding technique was employed to fabricate PM. Histological studies revealed that the PM, owing to their geometry/design, formed wider and deeper microconduits when compared to ADM of similar length. Approximately 6.84- and 6.11-fold increase in the cumulative amount (48 h) of AMLO permeated was observed with 1.5 mm ADM and PM-3 treatments respectively, when compared to passive permeation amounts. Good correlations (R2 > 0.89) were observed between different dimensionless parameters with scaling analyses. The enhancement in AMLO permeation was found to be in the order of 1.5 mm ADM ≥ PM-3 > 1.2 mm ADM > 0.6 mm ADM ≥PM-1 > passive. The study suggests that MN application enhances the AMLO transdermal permeation and the geometrical parameters of MNs play an important role in the degree of such enhancement.
Description: This is a post-peer-review, pre-copyedit version of an article published in Drug Delivery and Translational Research. The final authenticated version is available online at: http://dx.doi.org/10.1007/s13346-017-0361-z
Sponsor: This study was funded jointly by the Department of Science and Technology (DST), Ministry of Science and Technology, Govt. of India, and the British Council, London, UK, under DST-UKIERI scheme (DST/INT/UK/P-60/2014) to Buchi N. Nalluri and Diganta B. Das.
Version: Accepted for publication
DOI: 10.1007/s13346-017-0361-z
URI: https://dspace.lboro.ac.uk/2134/24669
Publisher Link: http://dx.doi.org/10.1007/s13346-017-0361-z
ISSN: 2190-393X
Appears in Collections:Published Articles (Chemical Engineering)

Files associated with this item:

File Description SizeFormat
Effect of microneedles.pdfAccepted version2.15 MBAdobe PDFView/Open


SFX Query

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.