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Title: Microneedle assisted transdermal delivery of zolmitriptan: effect of microneedle geometry, in vitro permeation experiments, scaling analyses and numerical simulations
Authors: Uppuluri, Chandrateja
Devineni, Jyothirmayee
Han, Tao
Nayak, Atul
Nair, Karthik J.
Whiteside, Benjamin R.
Das, Diganta Bhusan
Nalluri, Buchi N.
Issue Date: 2017
Publisher: © Taylor & Francis
Citation: UPPULURI, C. ...et al., 2017. Microneedle assisted transdermal delivery of zolmitriptan: effect of microneedle geometry, in vitro permeation experiments, scaling analyses and numerical simulations. Drug Development and Industrial Pharmacy, 43(8), pp.1292-1303.
Abstract: Objective: The present study was aimed to investigate the effect of salient microneedle (MN) geometry parameters like length, density, shape and type on transdermal permeation enhancement of Zolmitriptan (ZMT). Methods: Two types of MN devices viz. AdminPatch® arrays (ADM) (0.6, 0.9, 1.2 and 1.5mm lengths) and laboratory fabricated polymeric MNs (PM) of 0.6mm length were employed. In the case of PMs, arrays were applied thrice at different places within a 1.77cm2 skin area (PM-3) to maintain the MN density closer to 0.6mm ADM. Scaling analyses was done using dimensionless parameters like concentration of ZMT (Ct/Cs), thickness (h/L) and surface area of the skin (Sa/L2). Results: Micro-injection moulding technique was employed to fabricate PM. Histological studies revealed that the PM, owing to their geometry/design, formed wider and deeper microconduits when compared to ADM of similar length. Approximately 3.17 and 3.65 fold increase in ZMT flux values were observed with 1.5mm ADM and PM-3 applications when compared to the passive studies. Good correlations were observed between different dimensionless parameters with scaling analyses. Numerical simulations, using MATLAB and COMSOL software, based on experimental data and histological images provided information regarding the ZMT skin distribution after MN application. Discussion: Both from experimental studies and simulations, it was inferred that PM were more effective in enhancing the transdermal delivery of ZMT when compared to ADM. Conclusion: The study suggests that MN application enhances the ZMT transdermal permeation and the geometrical parameters of MNs play an important role in the degree of such enhancement.
Description: This is an Accepted Manuscript of an article published by Taylor & Francis in Drug Development and Industrial Pharmacy on 20 Apr 2017, available online: http://dx.doi.org/10.1080/03639045.2017.1313862
Sponsor: This research work was funded by DST, Ministry of Science and Technology, Govt. of India and the British Council, London, UK, under the DST-UKIERI scheme (DST/INT/UK/P-60/2014).
Version: Accepted for publication
DOI: 10.1080/03639045.2017.1313862
URI: https://dspace.lboro.ac.uk/2134/24770
Publisher Link: http://dx.doi.org/10.1080/03639045.2017.1313862
ISSN: 1520-5762
Appears in Collections:Published Articles (Chemical Engineering)

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