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Title: Dose-dependent effects of dietary nitrate on the oxygen cost of moderate-intensity exercise: acute vs. chronic supplementation
Authors: Wylie, Lee J.
Ortiz de Zevallos, Joaquin
Isidore, Taro
Nyman, Lara
Vanhatalo, Anni
Bailey, Stephen J.
Jones, Andrew M.
Keywords: Nitrate supplementation
Nitrite
Nitric oxide
Exercise efficiency
O2 uptake
Issue Date: 2016
Publisher: © Elsevier Inc.
Citation: WYLIE, L.J. ... et al., 2016. Dose-dependent effects of dietary nitrate on the oxygen cost of moderate-intensity exercise: acute vs. chronic supplementation. Nitric Oxide, 57 pp. 30 - 39.
Abstract: Purpose To investigate whether chronic supplementation with a low or moderate dose of dietary nitrate (NO3−) reduces submaximal exercise oxygen uptake (View the MathML sourceO2) and to assess whether or not this is dependent on acute NO3− administration prior to exercise. Methods Following baseline tests, 34 healthy subjects were allocated to receive 3 mmol NO3−, 6 mmol NO3− or placebo. Two hours following the first ingestion, and after 7, 28 and 30 days of supplementation, subjects completed two moderate-intensity step exercise tests. On days 28 and 30, subjects in the NO3− groups completed the test 2 h post consumption of a NO3− dose (CHR + ACU) and a placebo dose (CHR). Results Plasma nitrite concentration ([NO2−]) was elevated in a dose-dependent manner at 2 h, 7 days and 28–30 days on the CHR + ACU visit. Compared to pre-treatment baseline, 6 mmol NO3− reduced the steady-state View the MathML sourceO2 during moderate-intensity exercise by 3% at 2 h (P = 0.06), 7 days and at 28–30 days (both P < 0.05) on the CHR + ACU visit, but was unaffected by 3 mmol NO3− at all measurement points. On the CHR visit in the 6 mmol group, plasma [NO2−] had returned to pre-treatment baseline, but the steady-state View the MathML sourceO2 remained reduced. Conclusion Up to ∼4 weeks supplementation with 6 but not 3 mmol NO3− can reduce submaximal exercise View the MathML sourceO2. A comparable reduction in submaximal exercise View the MathML sourceO2 following chronic supplementation with 6 mmol NO3− can be achieved both with and without the acute ingestion of NO3− and associated elevation of plasma [NO2−].
Description: This article was published in the journal Nitric Oxide [© Elsevier Inc.] and the definitive version is available at: http://dx.doi.org/10.1016/j.niox.2016.04.004
Sponsor: Financial support for this study was provided by the Gatorade Sports Science Institute, a division of PepsiCo, Inc.
Version: Accepted for publication
DOI: 10.1016/j.niox.2016.04.004
URI: https://dspace.lboro.ac.uk/2134/24834
Publisher Link: http://dx.doi.org/10.1016/j.niox.2016.04.004
ISSN: 1089-8603
Appears in Collections:Published Articles (Sport, Exercise and Health Sciences)

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