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|Title: ||Dose-dependent effects of dietary nitrate on the oxygen cost of moderate-intensity exercise: acute vs. chronic supplementation|
|Authors: ||Wylie, Lee J.|
Ortiz de Zevallos, Joaquin
Bailey, Stephen J.
Jones, Andrew M.
|Keywords: ||Nitrate supplementation|
|Issue Date: ||2016|
|Publisher: ||© Elsevier Inc.|
|Citation: ||WYLIE, L.J. ... et al., 2016. Dose-dependent effects of dietary nitrate on the oxygen cost of moderate-intensity exercise: acute vs. chronic supplementation. Nitric Oxide, 57 pp. 30 - 39.|
To investigate whether chronic supplementation with a low or moderate dose of dietary nitrate (NO3−) reduces submaximal exercise oxygen uptake (View the MathML sourceO2) and to assess whether or not this is dependent on acute NO3− administration prior to exercise.
Following baseline tests, 34 healthy subjects were allocated to receive 3 mmol NO3−, 6 mmol NO3− or placebo. Two hours following the first ingestion, and after 7, 28 and 30 days of supplementation, subjects completed two moderate-intensity step exercise tests. On days 28 and 30, subjects in the NO3− groups completed the test 2 h post consumption of a NO3− dose (CHR + ACU) and a placebo dose (CHR).
Plasma nitrite concentration ([NO2−]) was elevated in a dose-dependent manner at 2 h, 7 days and 28–30 days on the CHR + ACU visit. Compared to pre-treatment baseline, 6 mmol NO3− reduced the steady-state View the MathML sourceO2 during moderate-intensity exercise by 3% at 2 h (P = 0.06), 7 days and at 28–30 days (both P < 0.05) on the CHR + ACU visit, but was unaffected by 3 mmol NO3− at all measurement points. On the CHR visit in the 6 mmol group, plasma [NO2−] had returned to pre-treatment baseline, but the steady-state View the MathML sourceO2 remained reduced.
Up to ∼4 weeks supplementation with 6 but not 3 mmol NO3− can reduce submaximal exercise View the MathML sourceO2. A comparable reduction in submaximal exercise View the MathML sourceO2 following chronic supplementation with 6 mmol NO3− can be achieved both with and without the acute ingestion of NO3− and associated elevation of plasma [NO2−].|
|Description: ||This article was published in the journal Nitric Oxide [© Elsevier Inc.] and the definitive version is available at: http://dx.doi.org/10.1016/j.niox.2016.04.004|
|Sponsor: ||Financial support for this study was provided by the Gatorade
Sports Science Institute, a division of PepsiCo, Inc.|
|Version: ||Accepted for publication|
|Publisher Link: ||http://dx.doi.org/10.1016/j.niox.2016.04.004|
|Appears in Collections:||Published Articles (Sport, Exercise and Health Sciences)|
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