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|Title: ||Sarcopenic obesity, weight loss, and mortality: The English Longitudinal Study of Ageing|
|Authors: ||Hamer, Mark|
|Issue Date: ||2017|
|Publisher: ||© American Society for Nutrition|
|Citation: ||HAMER, M. and O'DONOVAN, G., 2017. Sarcopenic obesity, weight loss, and mortality: The English Longitudinal Study of Ageing. The American Journal of Clinical Nutrition, 106(1), pp.125-129.|
|Abstract: ||Background: Age-related sarcopenia describes loss of muscle strength and often accompanies an increase in adiposity in elderly participants.
Objectives: We examined the association of sarcopenic obesity, and changes in muscle strength and weight with risk of mortality.
Design: Participants were 6,864 community dwelling men and women (mean±SD age 66.2 ± 6 9.5 years, 45.6% men) from the English Longitudinal Study of Ageing. Handgrip strength and body mass index were measured at baseline and at four years follow-up. Individual participant data were linked with death records from National Health Service registries. Sarcopenic obesity was defined as obese individuals (body mass index [BMI] ≥ 30 kg/m2) in the lowest tertile of sex specific grip strength (<35.3 kg men; < 19.6kg women).
Results: Over an average follow up of 8 years there were 906 deaths. Compared with the reference group (normal BMI and highest hand grip tertile), the risk of all-cause mortality increased with reducing grip strength within each BMI category. For participants in the lowest hand grip tertile there was little difference in risk between normal BMI (Hazard ratio=3.25; 95% CI, 1.86, 5.65), overweight (2.50;1.44, 4.35), and obese (2.66; 1.86, 3.80), after adjustment for covariates. Compared to participants with stable weight and grip strength, risk of all-cause mortality was significantly greater in those experiencing weight loss over 4 years (2.21;1.32, 3.71) and reduced hand grip strength (1.53;1.07, 2.17), with the highest risk in those with weight loss and reduced strength (3.77; 2.54, 5.60).
Conclusion: Sarcopenic obesity did not confer any greater risk than sarcopenia alone. Weight loss in combination with sarcopenia presented the greatest risk of mortality.|
|Description: ||This paper is embargoed until 24 May 2018|
|Sponsor: ||Hamer acknowledges support from the National Institute for Health Research (NIHR) Leicester Biomedical Research Centre, which is a partnership between University Hospitals of Leicester NHS Trust, Loughborough University and the University of Leicester.|
|Version: ||Accepted for publication|
|Publisher Link: ||https://doi.org/10.3945/ajcn.117.152488|
|Related Resource: ||10.3945/ajcn.117.152488|
|Appears in Collections:||Closed Access (Sport, Exercise and Health Sciences)|
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