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Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/24937

Title: Transferrin modified graphene oxide for glioma-targeted drug delivery: in vitro and in vivo evaluations
Authors: Liu, Guodong
Shen, He
Mao, Jinning
Zhang, Liming
Jiang, Zhen
Sun, Tao
Lan, Qing
Zhang, Zhijun
Keywords: Chemotherapy
Doxorubicin
Glioma
Graphene oxide
In vivo
Transferrin
Issue Date: 2013
Publisher: © ACS Publications
Citation: LIU, G. ... et al, 2013. Transferrin modified graphene oxide for glioma-targeted drug delivery: in vitro and in vivo evaluations. ACS Applied Materials & Interfaces, 5 (15), pp.6909-6914
Abstract: Transferrin (Tf), an iron-transporting serum glycoprotein that binds to receptors overexpressed at the surface of glioma cells, was chosen as the ligand to develop Tf-conjugated PEGylated nanoscaled graphene oxide (GO) for loading and glioma targeting delivery of anticancer drug doxorubicin (Dox) (Tf-PEG-GO-Dox). Tf-GO with lateral dimensions of 100–400 nm exhibited a Dox loading ratio up to 115.4%. Compared with Dox-loaded PEGylated GO (PEG-GO-Dox) and free Dox, Tf-PEG-GO-Dox displayed greater intracellular delivery efficiency and stronger cytotoxicity against C6 glioma cells. A competition test showed that Tf was essential to glioma targeting in vitro. The HPLC assay for Dox concentration in tumor tissue and contrapart tissue of the brain demonstrated that Tf-PEG-GO-Dox could deliver more Dox into tumor in vivo. The life span of tumor bearing rats after the administration of Tf-PEG-GO-Dox was extended significantly compared to the rats treated with saline, Dox, and PEG-GO-Dox. In conclusion, we developed Tf-PEG-GO-Dox which exhibited significantly improved therapeutic efficacy for glioma both in vitro and in vivo.
Description: This paper is Closed Access.
Version: Published
DOI: 10.1021/am402128s
URI: https://dspace.lboro.ac.uk/2134/24937
Publisher Link: http://dx.doi.org/10.1021/am402128s
ISSN: 1944-8244
Appears in Collections:Closed Access (Chemical Engineering)

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