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Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/24975

Title: Photo-crosslinkable microcapsules formed by polyelectrolyte copolymer and modified collagen for rat hepatocyte encapsulation
Authors: Quek, Chai-Hoon
Li, Jun
Sun, Tao
Chan, Melinda Ling Hou
Mao, Hai-Quan
Gan, Leong Ming
Leong, Kam W.
Yu, Hanry
Keywords: Photo-crosslinking
Microcapsule
Cell-encapsulation
Polyelectrolyte
Collagen
Hepatocyte
Issue Date: 2004
Publisher: © Elsevier
Citation: QUEK, C.H. ... et al, 2004. Photo-crosslinkable microcapsules formed by polyelectrolyte copolymer and modified collagen for rat hepatocyte encapsulation. Biomaterials, 25 (17), pp.3531-3540
Abstract: New anionic polyelectrolyte tetra-copolymers with photo-crosslinkable 4-(4-methoxycinnamoyl)phenyl methacrylate monomer in addition to a HEMA-MMA-MAA ter-copolymer system were synthesized. The tetra-copolymers were used to form photo-crosslinkable microcapsules with modified collagen by complex coacervation for rat hepatocytes encapsulation. The hepatocytes were encapsulated within a two-layered membrane comprising of modified collagen as the inner core and an outer photo-crosslinkable copolymer shell. Upon photo-crosslinking of the microcapsules with UV–Vis light irradiation, the mechanical strength and chemical stability of the microcapsules, and the cellular functions of the encapsulated hepatocytes were enhanced. Particularly, the mechanical stability of the microcapsules was dramatically strengthened. The new photo-crosslinkable tetra-copolymer formulation described in this article has opened a way to the development of hepatocyte microencapsulation technology for bioartifical liver assist device.
Description: This paper is closed access.
Version: Closed access
DOI: 10.1016/j.biomaterials.2003.09.112
URI: https://dspace.lboro.ac.uk/2134/24975
Publisher Link: http://dx.doi.org/10.1016/j.biomaterials.2003.09.112
ISSN: 0142-9612
Appears in Collections:Closed Access (Chemical Engineering)

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