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Title: Microfluidic hydrodynamic focusing based synthesis of POPC liposomes for model biological systems
Authors: Mijajlovic, M.
Wright, D.
Zivkovic, Vladimir
Bi, J.X.
Biggs, Mark J.
Keywords: Liposomes
Mode l biological systems
Drug delivery
Artificial cells
Issue Date: 2013
Publisher: © Elsevier
Citation: MIJAJLOVIC, M., 2013. Microfluidic hydrodynamic focusing based synthesis of POPC liposomes for model biological systems. Colloids and Surfaces B: Biointerfaces, 104, pp. 276-281.
Abstract: Lipid vesicles have received significant attention in areas ranging from pharmaceutical and biomedical engineering to novel materials and nanotechnology. Microfluidic-based synthesis of liposomes offers a number of advantages over the more traditional synthesis methods such as extrusion and sonication. One such microfluidic approach is microfluidic hydrodynamic focusing (MHF), which has been used to synthesize nanoparticles and vesicles of various lipids. We show here that this method can be utilized in synthesis of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) vesicles with controllable size. Since POPC is among the primary constituents of cellular membranes, this work is of direct applicability to modelling of biological systems and development of nano-containers with higher biologic compatibility for pharmaceutical and medical applications. © 2012 Elsevier B.V.
Description: This paper was accepted for publication in the journal Colloids and Surfaces B: Biointerfaces and the definitive published version is available at http://dx.doi.org/10.1016/j.colsurfb.2012.12.020
Version: Accepted for publication
DOI: 10.1016/j.colsurfb.2012.12.020
URI: https://dspace.lboro.ac.uk/2134/25142
Publisher Link: http://dx.doi.org/10.1016/j.colsurfb.2012.12.020
ISSN: 0927-7765
Appears in Collections:Published Articles (Chemistry)

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