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Arming your Health Study - Accepted manuscript 16.05.2017.pdf (306.63 kB)

Breaking up sedentary time with seated upper body activity can regulate metabolic health in obese high risk adults: A randomised crossover trial

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journal contribution
posted on 2017-05-26, 13:35 authored by Matthew McCarthy, Charlotte L. Edwardson, Melanie J. Davies, Joseph Henson, Alex V. Rowlands, James KingJames King, Danielle H. Bodicoat, Kamlesh Khunti, Thomas E. Yates
Aims: To investigate the impact of performing short bouts of seated upper body activity on postprandial blood glucose and insulin levels during prolonged sitting. Materials and methods: Participants undertook two 7·5 hour experimental conditions in a randomised order: 1) prolonged sitting only 2) sitting interspersed with 5 minutes of seated arm ergometry every 30 minutes. Blood samples were obtained while fasting and throughout the postprandial period following ingestion of two standardised meals. Incremental Area Under the Curve (iAUC) was calculated for glucose and insulin throughout each experimental condition. Paired samples t-test assessed the difference in iAUC data between conditions for glucose (primary outcome) and insulin (secondary outcome). Results: Thirteen obese adults (7 female; 6 male; age: 66 ± 6 years, BMI: 33.8 ± 3.8 kg/m2 (mean ± SD) completed this investigation. Compared with the prolonged sitting only condition, the implementation of seated arm ergometry every 30 minutes significantly reduced mean [95% CI] blood glucose iAUC (from 7.4 [5.2, 9.5] mmol·L-1·h to 3.1 [1.3, 5.0] mmol·L-1·h, p = 0.001). Significant reductions in mean insulin iAUC (from 696 [359, 1032] mU⋅L-1 ⋅h to 554 [298, 811] mU⋅L-1 ⋅h, p = 0.047) were also observed. Conclusion: Performing short bouts of arm ergometry during prolonged sitting attenuated postprandial glycaemia despite maintaining a seated posture. This may have clinical significance for those with weight bearing difficulty who may struggle with postural change.

Funding

This trial was funded by the National Institute for Health Research (NIHR) Leicester-Loughborough Diet, Lifestyle and Physical Activity Biomedical Research Unit.

History

School

  • Sport, Exercise and Health Sciences

Published in

Diabetes, Obesity and Metabolism: a journal of pharmacology and therapeutics

Citation

MCCARTHY, M. ... et al, 2017. Breaking up sedentary time with seated upper body activity can regulate metabolic health in obese high risk adults: A randomised crossover trial. Diabetes, Obesity and Metabolism, 19(12), pp. 1732-1739.

Publisher

© Wiley

Version

  • AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Acceptance date

2017-05-18

Publication date

2017

Notes

This is the peer reviewed version of the following article: MCCARTHY, M. ... et al, 2017. Breaking up sedentary time with seated upper body activity can regulate metabolic health in obese high risk adults: A randomised crossover trial. Diabetes, Obesity and Metabolism, 19(12), pp. 1732-1739, which has been published in final form at https://doi.org/10.1111/dom.13016. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.

ISSN

1462-8902

eISSN

1463-1326

Language

  • en

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