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Title: Continuous synthesis of PVP stabilized biocompatible gold nanoparticles with a controlled size using a 3D glass capillary microfluidic device
Authors: Bandulasena, Monalie V.
Vladisavljevic, Goran T.
Odunmbaku, Omololu G.
Benyahia, Brahim
Keywords: Gold nanoparticles
Glass capillary microfluidics
Continuous production
Ascorbic acid
Microfluidic micro-mixing
Issue Date: 2017
Publisher: Elsevier (© the Authors)
Citation: BANDULASENA, M.V. ... et al, 2017. Continuous synthesis of PVP stabilized biocompatible gold nanoparticles with a controlled size using a 3D glass capillary microfluidic device. Chemical Engineering Science, 171, pp.233-243
Abstract: A reliable glass capillary microfluidic method was developed for a continuous production of well-controlled gold nanoparticles (AuNPs) capped with polyvinylpyrrolidone (PVP) of different molecular weights (PVP K15, PVP K30 and PVP K90). A two-phase co-flow glass capillary microfluidic device with an injection orifice diameter ranging between 100 and 240 µm was used to synthesise 100–240 µm was used to synthesise AuNPs via the chemical reduction between tetrachloroaurate trihydrate (HAuCl4·3H2O) and ascorbic acid. AuNPs with an average diameter between 48 and 135 nm were synthesised, as determined by DLS measurements. Decreasing the injection orifice diameter, increasing the flow rate of ascorbic acid stream and its pH resulted in smaller AuNPs. The polydispersity index (PDI) was found to be independent on the injection orifice diameter or the molecular weight of PVP, but increased with the increase of flow rate and the pH of ascorbic acid stream. The stability study over 6-week period confirmed that PVP K30 with an average Mw of 40000 g/mol was the best capping agent to synthesize and stabilise smaller AuNPs. The reactor fouling due to deposition of AuNPs on reactor walls and orifices was mitigated by hydrophobization of reactor/capillary walls with octadecyltrimethoxisilane and the use of ascorbic acid solution of higher pH.
Description: This paper was published as Gold Open Access by Elsevier under the CC BY 4.0 licence.
Sponsor: This paper was supported by the Engineering and Physical Sciences Research Council [grant numbers EP/N032675/1 and EP/H029923/1].
Version: Published
DOI: 10.1016/j.ces.2017.05.035
URI: https://dspace.lboro.ac.uk/2134/25190
Publisher Link: http://dx.doi.org/10.1016/j.ces.2017.05.035
Related Resource: https://doi.org/10.17028/rd.lboro.5182837
ISSN: 0009-2509
Appears in Collections:Published Articles (Chemical Engineering)

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