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|Title: ||Plasma phospholipid fatty acid profile confirms compliance to a novel saturated fat-reduced, monounsaturated fat-enriched dairy product intervention in adults at moderate cardiovascular risk: a randomized controlled trial|
|Authors: ||Markey, Oonagh|
Kliem, Kirsty E.
Fagan, Colette C.
Wang, Laura Y.
Grandison, Alistair S.
Humphries, David J.
Jackson, Kim G.
Givens, David Ian
Lovegrove, Julie A.
|Keywords: ||Cardiovascular disease|
Dietary fat composition
Monounsaturated fatty acids
Saturated fatty acids
|Issue Date: ||2017|
|Publisher: ||BioMed Central © The Author(s)|
|Citation: ||MARKEY, O. ... et al, 2017. Plasma phospholipid fatty acid profile confirms compliance to a novel saturated fat-reduced, monounsaturated fat-enriched dairy product intervention in adults at moderate cardiovascular risk: a randomized controlled trial. Nutrition Journal, 16 (33)|
|Abstract: ||Background: Dairy products are a major contributor to dietary SFA. Partial replacement of milk SFA with unsaturated fatty acids (FAs) is possible through oleic-acid rich supplementation of the dairy cow diet. To assess adherence to the intervention of SFA-reduced, MUFA-enriched dairy product consumption in the RESET (REplacement of SaturatEd fat in dairy on Total cholesterol) study using 4-d weighed dietary records, in addition to plasma phospholipid FA (PL-FA) status. Methods: In a randomised, controlled, crossover design, free-living UK participants identified as moderate risk for CVD (n = 54) were required to replace habitually consumed dairy foods (milk, cheese and butter), with study products with a FA profile typical of retail products (control) or SFA-reduced, MUFA-enriched profile (modified), for two 12-week periods, separated by an 8-week washout period. A flexible food-exchange model was used to implement each isoenergetic high-fat, high-dairy diet (38% of total energy intake (%TE) total fat): control (dietary target: 19%TE SFA; 11%TE MUFA) and modified (16%TE SFA; 14%TE MUFA). Results: Following the modified diet, there was a smaller increase in SFA (17.2%TE vs. 19.1%TE; p < 0.001) and greater increase in MUFA intake (15.4%TE vs. 11.8%TE; p < 0.0001) when compared with the control. PL-FA analysis revealed lower total SFAs (p = 0.006), higher total cis-MUFAs and trans-MUFAs (both p < 0.0001) following the modified diet. Conclusion: The food-exchange model was successfully used to achieve RESET dietary targets by partial replacement of SFAs with MUFAs in dairy products, a finding reflected in the PL-FA profile and indicative of objective dietary compliance.|
|Description: ||This is an Open Access Article. It is published by BioMed under the Creative Commons Attribution 4.0 International Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/|
|Sponsor: ||This work was supported by funding from the Medical Research Council (United Kingdom; Ref: MR/K020218/1). Arla Foods UK and AAK UK supplied in kind the commercially available dairy products and oils according to our specification. Arla Foods UK and AAK UK had no role in the design, analysis or writing of this article.|
|Publisher Link: ||http://dx.doi.org/10.1186/s12937-017-0249-2|
|Appears in Collections:||Published Articles (Sport, Exercise and Health Sciences)|
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