Loughborough University
Leicestershire, UK
LE11 3TU
+44 (0)1509 263171
Loughborough University

Loughborough University Institutional Repository

Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/25339

Title: The effect of active pharmaceutical ingredients on aerosol electrostatic charges from pressurized metered dose inhalers
Authors: Chen, Yang
Young, Paul M.
Fletcher, David F.
Chan, Hak Kim
Long, Edward J.
Lewis, David
Church, Tanya
Traini, Daniela
Keywords: Aerosols
APIs
Electrostatic charges
Metered dose inhalers
Issue Date: 2015
Publisher: © Springer
Citation: CHEN, Y. ... et al., 2015. The effect of active pharmaceutical ingredients on aerosol electrostatic charges from pressurized metered dose inhalers. Pharmaceutical Research, 32(9), pp.2928-2936.
Abstract: Purpose. This study investigated the effect of different active pharmaceutical ingredients (API) on aerosol electrostatic charges and aerosol performances for pressurized metered dose inhalers (pMDIs), using both insulating and conducting actuators. Methods. Five solution-based pMDIs containing different API ingredients including: beclomethasone dipropionate (BDP), budesonide (BUD), flunisolide (FS), salbutamol base (SB) and ipratropium bromide (IPBr) were prepared using pressure filling technique. Actuator blocks made from nylon, polytetrafluoroethylene (PTFE) and aluminium were manufactured with 0.3 mm nominal orifice diameter and cone nozzle shape. Aerosol electrostatics for each pMDI formulation and actuator were evaluated using the electrical low-pressure impactor (ELPI) and drug depositions were analysed using high performance liquid chromatography (HPLC). Results. All three actuator materials showed the same net charge trend across the five active drug ingredients, with BDP, BUD and FS showing positive net charges for both nylon and PTFE actuators, respectively. While SB and IPBr had significantly negative net charges across the three different actuators, which correlates to the ionic functional groups present on the drug molecule structures. Conclusions. The API present in a pMDI has a dominant effect on the electrostatic properties of the formulation, overcoming the charge effect arising from the actuator materials. Results have shown that the electrostatic charges for a solution-based pMDI could be related to the interactions of the chemical ingredients and change in the work function for the overall formulation.
Description: The final publication is available at Springer via: http://dx.doi.org/10.1007/s11095-015-1674-6.
Sponsor: This research was supported under Australian Research Council’s Linkage Projects funding scheme (project number ARCLP100200156) and Chiesi Ltd, Chippenham, Wiltshire, United Kingdom. Professor Traini is the recipient of an Australian Research Council Future Fellowship (project number FT12010063). Professor Young is the recipient of an Australian Research Council Future Fellowship (project number FT110100996).
Version: Submitted for publication
DOI: 10.1007/s11095-015-1674-6
URI: https://dspace.lboro.ac.uk/2134/25339
Publisher Link: http://dx.doi.org/10.1007/s11095-015-1674-6
ISSN: 0724-8741
Appears in Collections:Published Articles (Mechanical, Electrical and Manufacturing Engineering)

Files associated with this item:

File Description SizeFormat
25339.pdfSubmitted version377.8 kBAdobe PDFView/Open

 

SFX Query

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.