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Title: The role of TLR4, TNF-α and IL-1β in type 2 diabetes mellitus development within a North Indian Population.
Authors: Doody, Natalie E.
Dowejko, Monika
Akam, Elizabeth Claire
Cox, Nick
Bhatti, Jasvinder Singh
Singh, Puneetpal
Mastana, Sarabjit S.
Keywords: Type 2 diabetes mellitus
TLR4 896
TNF-α -308
IL-1β -511
Inflammatory gene polymorphisms
North Indian population
Issue Date: 2017
Publisher: © Wiley
Citation: DOODY, N.E. ...et al., 2017. The role of TLR4, TNF-α and IL-1β in type 2 diabetes mellitus development within a North Indian Population.. Annals of Human Genetics, 81, pp. 141-146.
Abstract: This study investigated the role of IL-1β-511 (rs16944), TLR4-896 (rs4986790) and TNF-α-308 (rs1800629) polymorphisms in type 2 diabetes mellitus (T2DM) among an endogamous Northern Indian population. 414 participants (204 T2DM patients and 210 non-diabetic controls) were genotyped for IL-1β-511, TLR4-896 and TNF-α-308 loci. The C allele of IL-1β-511 was shown to increase T2DM susceptibility by 75% (OR: 1.75 [CI 1.32-2.33]). Having two parents affected by T2DM increased susceptibility by 5.7 times (OR: 5.693 [CI 1.431-22.648]). In this study, we have demonstrated a conclusive association with IL-1β-511 locus and IL1B-511-TLR4-896 diplotype (CC-AA) and T2DM, which warrants further comprehensive analyses in larger cohorts.
Description: This paper is in closed access until 16th June 2018.
Version: Published
DOI: 10.1111/ahg.12197
URI: https://dspace.lboro.ac.uk/2134/25549
Publisher Link: http://dx.doi.org/10.1111/ahg.12197
ISSN: 1469-1809
Appears in Collections:Closed Access (Sport, Exercise and Health Sciences)

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