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Title: N-3 fatty acids and asthma
Authors: Kumar, Aishwarya
Mastana, Sarabjit S.
Lindley, Martin R.
Keywords: Asthma
N-3 Fatty acids
Omega-3 fatty acids
Fish oils
Inflammation
Issue Date: 2016
Publisher: © The Authors. Published by Cambridge University Press.
Citation: KUMAR, A., MASTANA, S.S. and LINDLEY, M.R., 2016. N-3 Fatty acids and asthma. Nutrition Research Reviews, 29(1), pp. 1-16.
Abstract: Copyright © 2016 The Authors. Asthma is one of the most common and prevalent problems worldwide affecting over 300 million individuals. There is some evidence from observational and intervention studies to suggest a beneficial effect of n-3 PUFA in inflammatory diseases, specifically asthma. Marine-based n-3 PUFA have therefore been proposed as a possible complementary/alternative therapy for asthma. The proposed anti-inflammatory effects of n-3 fatty acids may be linked to a change in cell membrane composition. This altered membrane composition following n-3 fatty acid supplementation (primarily EPA and DHA) can modify lipid mediator generation via the production of eicosanoids with a reduced inflammatory potential/impact. A recently identified group of lipid mediators derived from EPA including E-series resolvins are proposed to be important in the resolution of inflammation. Reduced inflammation attenuates the severity of asthma including symptoms (dyspnoea) and exerts a bronchodilatory effect. There have been no major health side effects reported with the dietary supplementation of n-3 fatty acids or their mediators; consequently supplementing with n-3 fatty acids is an attractive non-pharmacological intervention which may benefit asthma.
Description: This article has been published in a revised form in Nutrition Research Reviews http://dx.doi.org/10.1017/S0954422415000116. This version is free to view and download for private research and study only. Not for re-distribution, re-sale or use in derivative works. © copyright holder.
Version: Published
DOI: 10.1017/S0954422415000116
URI: https://dspace.lboro.ac.uk/2134/25681
Publisher Link: http://dx.doi.org/10.1017/S0954422415000116
ISSN: 0954-4224
Appears in Collections:Published Articles (Sport, Exercise and Health Sciences)

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