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|Title: ||Investigation of the evolution of crystal size and shape during temperature cycling and in the presence of a polymeric additive using combined process analytical technologies|
|Authors: ||Simone, Elena|
Klapwijk, Anneke R.
Wilson, Chick C.
Nagy, Zoltan K.
|Issue Date: ||2017|
|Publisher: ||© American Chemical Society (ACS)|
|Citation: ||SIMONE, E. ...et al., 2017. Investigation of the evolution of crystal size and shape during temperature cycling and in the presence of a polymeric additive using combined process analytical technologies. Crystal Growth and Design, 17(4), pp. 1695-1706.|
|Abstract: ||© 2017 American Chemical Society. Crystal size and shape can be manipulated to enhance the qualities of the final product. In this work the steady-state shape and size of succinic acid crystals, with and without a polymeric additive (Pluronic P123) at 350 mL, scale is reported. The effect of the amplitude of cycles as well as the heating/cooling rates is described, and convergent cycling (direct nucleation control) is compared to static cycling. The results show that the shape of succinic acid crystals changes from plate- to diamond-like after multiple cycling steps, and that the time required for this morphology change to occur is strongly related to the type of cycling. Addition of the polymer is shown to affect both the final shape of the crystals and the time needed to reach size and shape steady-state conditions. It is shown how this phenomenon can be used to improve the design of the crystallization step in order to achieve more efficient downstream operations and, in general, to help optimize the whole manufacturing process.|
|Description: ||This paper is in closed access until 9th March 2018.|
|Sponsor: ||This work is funded through the European Research Council grant no. [280106-CrySys], EPSRC grants EP/I033459/1 (CMAC Centre) and EP/K503289/1 (Doctoral Training Centre in Continuous Manufacturing and Crystallisation).|
|Version: ||Accepted for publication|
|Publisher Link: ||http://dx.doi.org/10.1021/acs.cgd.6b01683|
|Appears in Collections:||Closed Access (Chemical Engineering)|
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