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Title: Investigation of the evolution of crystal size and shape during temperature cycling and in the presence of a polymeric additive using combined process analytical technologies
Authors: Simone, Elena
Klapwijk, Anneke R.
Wilson, Chick C.
Nagy, Zoltan K.
Issue Date: 2017
Publisher: American Chemical Society (ACS)
Citation: SIMONE, E. ...et al., 2017. Investigation of the evolution of crystal size and shape during temperature cycling and in the presence of a polymeric additive using combined process analytical technologies. Crystal Growth and Design, 17(4), pp. 1695-1706.
Abstract: Crystal size and shape can be manipulated to enhance the qualities of the final product. In this work the steady-state shape and size of succinic acid crystals, with and without a polymeric additive (Pluronic P123) at 350 mL, scale is reported. The effect of the amplitude of cycles as well as the heating/cooling rates is described, and convergent cycling (direct nucleation control) is compared to static cycling. The results show that the shape of succinic acid crystals changes from plate- to diamond-like after multiple cycling steps, and that the time required for this morphology change to occur is strongly related to the type of cycling. Addition of the polymer is shown to affect both the final shape of the crystals and the time needed to reach size and shape steady-state conditions. It is shown how this phenomenon can be used to improve the design of the crystallization step in order to achieve more efficient downstream operations and, in general, to help optimize the whole manufacturing process.
Description: This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited. Special Issue published as part of a Crystal Growth and Design virtual special issue of selected papers presented at the 12th International Workshop on the Crystal Growth of Organic Materials (CGOM12 Leeds, UK).
Sponsor: This work is funded through the European Research Council grant no. [280106-CrySys], EPSRC grants EP/I033459/1 (CMAC Centre) and EP/K503289/1 (Doctoral Training Centre in Continuous Manufacturing and Crystallisation).
Version: Published
DOI: 10.1021/acs.cgd.6b01683
URI: https://dspace.lboro.ac.uk/2134/26035
Publisher Link: http://dx.doi.org/10.1021/acs.cgd.6b01683
ISSN: 1528-7483
Appears in Collections:Published Articles (Chemical Engineering)

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