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Title: Global associations between regional gray matter volume and diverse complex cognitive functions: evidence from a large sample study
Authors: Takeuchi, Hikaru
Taki, Yasuyuki
Nouchi, Rui
Yokoyama, Ryoichi
Kotozaki, Yuka
Nakagawa, Seishu
Sekiguchi, Atsushi
Izuka, Kunio
Yamamoto, Yuki
Hanawa, Sugiko
Araki, Tsuyoshi
Miyauchi, Carlos M.
Shinada, Takamitsu
Sakaki, Kohei
Sassa, Yuko
Nozawa, Takayuki
Ikeda, Shigeyuki
Yokota, Susumu
Magistro, Daniele
Kawashima, Ryuta
Issue Date: 2017
Publisher: © the Authors. Published by the Nature Publishing Group
Citation: TAKEUCHI, H. ...et al., 2017. Global associations between regional gray matter volume and diverse complex cognitive functions: evidence from a large sample study. Scientific Reports, 7: 10014 .
Abstract: Correlations between regional gray matter volume (rGMV) and psychometric test scores have been measured to investigate the neural bases for individual differences in complex cognitive abilities (CCAs). However, such studies have yielded different rGMV correlates of the same CCA. Based on the available evidence, we hypothesized that diverse CCAs are all positively but only weakly associated with rGMV in widespread brain areas. To test this hypothesis, we used the data from a large sample of healthy young adults [776 males and 560 females; mean age: 20.8 years, standard deviation (SD) = 0.8] and investigated associations between rGMV and scores on multiple CCA tasks (including non-verbal reasoning, verbal working memory, Stroop interference, and complex processing speed tasks involving spatial cognition and reasoning). Better performance scores on all tasks except non-verbal reasoning were associated with greater rGMV across widespread brain areas. The effect sizes of individual associations were generally low, consistent with our previous studies. The lack of strong correlations between rGMV and specific CCAs, combined with stringent corrections for multiple comparisons, may lead to different and diverse findings in the field.
Description: This is an Open Access Article. It is published by Nature Publishing Group under the Creative Commons Attribution 4.0 Unported Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/
Sponsor: This study was supported by JST/RISTEX, JST/CREST, a Grant-in-Aid for Young Scientists (B) (KAKENHI 23700306), and a Grant-in-Aid for Young Scientists (A) (KAKENHI 25700012) from the Ministry of Education, Culture, Sports, Science, and Technology.
Version: Published
DOI: 10.1038/s41598-017-10104-8
URI: https://dspace.lboro.ac.uk/2134/26405
Publisher Link: https://doi.org/10.1038/s41598-017-10104-8
ISSN: 2045-2322
Appears in Collections:Published Articles (Sport, Exercise and Health Sciences)

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