CHRISTIE, J.K. and BRAUER, D.S., 2017. The role of fluoride in the nano‐heterogeneity of bioactive glasses. Physics and Chemistry of Glasses - European Journal of Glass Science and Technology Part B, 58(4), pp. 180-186.
Fluoride-‐containing bioactive phospho‐silicate
glasses have recently attracted interest for dental applications, particularly as remineralising additives in dentifrices, and are potentially attractive for bone regeneration, particularly in patients suffering from osteoporosis. The incorporation of fluoride into phospho‐silicate glasses is also attractive from a structural viewpoint: Fluoride complexes modifier ions rather than binding to the silicate network, and it thereby adds a significant ionic
contribution to the average character of chemical bonds in the system. Molecular dynamics simulations have suggested that this
also results in the formation of nano-eterogeneities. In this paper, we review the
current knowledge on the structural role of fluoride in bioactive glasses, with a particular focus on inhomogeneities on a nano-‐scale.