LEAPER, M.C., ALI, K. and INGHAM, A.J., 2017. Comparing the dynamic flow properties and compaction properties of pharmaceutical powder mixtures. Chemical Engineering and Technology, doi: 10.1002/ceat.201600651.
The dynamic flow properties and compaction characteristics of mannitol and
mannitol-sodium carbonate mixtures (80/20, 70/30 and 60/40 by mass) were measured
using a Freeman FT4 powder rheometer. The results showed that the mixtures containing
up to 30% sodium carbonate had better flow properties and improved compaction
characteristics when compared with mannitol alone. The study demonstrated the feasibility
of combining a more expensive pharmaceutical excipient with a cheaper ingredient, without
compromising desired powder characteristics. It may also provide a useful method for
assessing the suitability of new formulations for use as direct compression bases, as part of
a wider range of powder flow tests.
This paper is closed access until 18th October 2018.