LEAPER, M.C., ALI, K. and INGHAM, A.J., 2017. Comparing the dynamic flow properties and compaction properties of pharmaceutical powder mixtures. Chemical Engineering and Technology, In Press.
The dynamic flow properties and compaction characteristics of mannitol and
mannitol-sodium carbonate mixtures (80/20, 70/30 and 60/40 by mass) were measured
using a Freeman FT4 powder rheometer. The results showed that the mixtures containing
up to 30% sodium carbonate had better flow properties and improved compaction
characteristics when compared with mannitol alone. The study demonstrated the feasibility
of combining a more expensive pharmaceutical excipient with a cheaper ingredient, without
compromising desired powder characteristics. It may also provide a useful method for
assessing the suitability of new formulations for use as direct compression bases, as part of
a wider range of powder flow tests.
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