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Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/26620

Title: Comparing the dynamic flow properties and compaction properties of pharmaceutical powder mixtures
Authors: Leaper, Mark C.
Ali, Kashaf
Ingham, Andrew J.
Issue Date: 2018
Publisher: © Wiley
Citation: LEAPER, M.C., ALI, K. and INGHAM, A.J., 2018. Comparing the dynamic flow properties and compaction properties of pharmaceutical powder mixtures. Chemical Engineering and Technology, 41(1), pp. 102-107.
Abstract: The dynamic flow properties and compaction characteristics of mannitol and mannitol-sodium carbonate mixtures (80/20, 70/30 and 60/40 by mass) were measured using a Freeman FT4 powder rheometer. The results showed that the mixtures containing up to 30% sodium carbonate had better flow properties and improved compaction characteristics when compared with mannitol alone. The study demonstrated the feasibility of combining a more expensive pharmaceutical excipient with a cheaper ingredient, without compromising desired powder characteristics. It may also provide a useful method for assessing the suitability of new formulations for use as direct compression bases, as part of a wider range of powder flow tests.
Description: This paper is closed access until 18th October 2018.
Version: Accepted for publication
DOI: 10.1002/ceat.201600651
URI: https://dspace.lboro.ac.uk/2134/26620
Publisher Link: https://doi.org/10.1002/ceat.201600651
ISSN: 0930-7516
Appears in Collections:Closed Access (Chemical Engineering)

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