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Title: Long-term stability of droplet production by microchannel (step) emulsification in microfluidic silicon chips with large number of terraced microchannels
Authors: Vladisavljevic, Goran T.
Ekanem, Ekanem E.
Zhang, Zilin
Khalid, Nauman
Kobayashi, Isao
Nakajima, Mitsutoshi
Keywords: Microchannel emulsification
Step emulsification
Microfluidic scale-up
Composite polymer microparticles
Synthetic biodegradable polymers
Poly(d,l-lactic) acid
Issue Date: 2017
Publisher: © Elsevier
Citation: VLADISAVLJEVIC, G.T. ...et al., 2017. Long-term stability of droplet production by microchannel (step) emulsification in microfluidic silicon chips with large number of terraced microchannels. Chemical Engineering Journal, 333, pp. 380-391.
Abstract: A long-term production stability of oil-in-water emulsions by microchannel (step) emulsification was investigated using two cross flow silicon chips consisting of 540 or 1,850 microchannels fabricated on 10 parallel terraces. Each terrace was 9.54 mm long and consisted of 54 channels with a depth of 5 µm and a width of 18 µm (chip 1) or 185 channels with a depth of 4 µm and a width of 8 µm (chip 2). The dispersed phase was a mixture of 2 wt% polycaprolactone (PCL) and 1 wt% poly(d,l-lactic) acid (PLA) dissolved in dichloromethane and the continuous phase was 2 wt% poly(vinyl alcohol). After solvent evaporation, the droplets were transformed into highly uniform composite polymer particles with an average diameter of 8.8 or 4.9 µm. The percentages of active channels, droplet sizes and droplet generation frequencies at individual terraces were investigated in both chips to reveal any flow maldistribution. After 6 h of production in chip 1, overall 95% of the channels produced droplets and the percentage of active channels on each terrace was at least 91%. The percentage of active channels decreased by decreasing the size of the channels. The mean droplet size varied negligibly across individual terraces over 7 h. Slightly higher droplet generation frequencies and smaller percentages of active channels were observed at central terraces. The droplet generation frequencies at the channels located close to each other were similar, indicating that droplet formation dynamics was coupled. The droplet size was not affected by the dispersed phase flow rate.
Description: This paper is in closed access until 23rd September 2018.
Sponsor: The authors gratefully acknowledge the financial support from the JSPS-UK BRIDGE Fellowship (BR 130302) awarded to Dr Vladisavljevic.
Version: Accepted for publication
DOI: 10.1016/j.cej.2017.09.141
URI: https://dspace.lboro.ac.uk/2134/26674
Publisher Link: https://doi.org/10.1016/j.cej.2017.09.141
ISSN: 1385-8947
Appears in Collections:Closed Access (Chemical Engineering)

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