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Degradation mechanisms of bioresorbable polyesters. Part 2, Effects of initial molecular weight and residual monomer
journal contribution
posted on 2017-10-02, 08:41 authored by Andy GleadallAndy Gleadall, Jingzhe Pan, Marc-Anton Kruft, Minna KellomakiThis paper presents an understanding of how initial molecular weight and initial monomer fraction affect the degradation of bioresorbable polymers in terms of the underlying hydrolysis mechanisms. A mathematical model was used to analyse the effects of initial molecular weight for various hydrolysis mechanisms including noncatalytic random scission, autocatalytic random scission, noncatalytic end scission or autocatalytic end scission. Different behaviours were identified to relate initial molecular weight to the molecular weight half-life and to the time until the onset of mass loss. The behaviours were validated by fitting the model to experimental data for molecular weight reduction and mass loss of samples with different initial molecular weights. Several publications that consider initial molecular weight were reviewed. The effect of residual monomer on degradation was also analysed, and shown to accelerate the reduction of molecular weight and mass loss. An inverse square root law relationship was found between molecular weight half-life and initial monomer fraction for autocatalytic hydrolysis. The relationship was tested by fitting the model to experimental data with various residual monomer contents.
History
School
- Mechanical, Electrical and Manufacturing Engineering
Published in
Acta BiomaterialiaVolume
10Issue
5Pages
2233 - 2240Citation
GLEADALL, A. ... et al., 2014. Degradation mechanisms of bioresorbable polyesters. Part 2, Effects of initial molecular weight and residual monomer. Acta Biomaterialia, 10 (5), pp.2233-2240.Publisher
Elsevier (© Acta Materialia Inc.)Version
- AM (Accepted Manuscript)
Publisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/Acceptance date
2014-01-15Publication date
2014-01-26Copyright date
2014Notes
A.G. acknowledges an EPSRC PhD studentship.ISSN
1742-7061eISSN
1878-7568Publisher version
Language
- en