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Title: Degradation mechanisms of bioresorbable polyesters. Part 2, Effects of initial molecular weight and residual monomer
Authors: Gleadall, Andrew
Pan, Jingzhe
Kruft, Marc-Anton
Kellomaki, Minna
Issue Date: 2014
Publisher: Elsevier (© Acta Materialia Inc.)
Citation: GLEADALL, A. ... et al., 2014. Degradation mechanisms of bioresorbable polyesters. Part 2, Effects of initial molecular weight and residual monomer. Acta Biomaterialia, 10 (5), pp.2233-2240.
Abstract: This paper presents an understanding of how initial molecular weight and initial monomer fraction affect the degradation of bioresorbable polymers in terms of the underlying hydrolysis mechanisms. A mathematical model was used to analyse the effects of initial molecular weight for various hydrolysis mechanisms including noncatalytic random scission, autocatalytic random scission, noncatalytic end scission or autocatalytic end scission. Different behaviours were identified to relate initial molecular weight to the molecular weight half-life and to the time until the onset of mass loss. The behaviours were validated by fitting the model to experimental data for molecular weight reduction and mass loss of samples with different initial molecular weights. Several publications that consider initial molecular weight were reviewed. The effect of residual monomer on degradation was also analysed, and shown to accelerate the reduction of molecular weight and mass loss. An inverse square root law relationship was found between molecular weight half-life and initial monomer fraction for autocatalytic hydrolysis. The relationship was tested by fitting the model to experimental data with various residual monomer contents.
Description: A.G. acknowledges an EPSRC PhD studentship.
Version: Accepted for publication
DOI: 10.1016/j.actbio.2014.01.017
URI: https://dspace.lboro.ac.uk/2134/26776
Publisher Link: https://doi.org/10.1016/j.actbio.2014.01.017
ISSN: 1742-7061
Appears in Collections:Published Articles (Mechanical, Electrical and Manufacturing Engineering)

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