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Title: Keeping an eye on decellularized corneas: a review of methods, characterization and applications
Authors: Wilson, Samantha L.
Sidney, Laura E.
Dunphy, Siobhan E.
Rose, James B.
Hopkinson, Andrew
Issue Date: 2013
Publisher: Multidisciplinary Digital Publishing Institute (© the authors)
Citation: WILSON, S. ... et al., 2013. Keeping an eye on decellularized corneas: a review of methods, characterization and applications. Journal of Functional Biomaterials, 4 (3), pp.114-161.
Abstract: The worldwide limited availability of suitable corneal donor tissue has led to the development of alternatives, including keratoprostheses (Kpros) and tissue engineered (TE) constructs. Despite advances in bioscaffold design, there is yet to be a corneal equivalent that effectively mimics both the native tissue ultrastructure and biomechanical properties. Human decellularized corneas (DCs) could offer a safe, sustainable source of corneal tissue, increasing the donor pool and potentially reducing the risk of immune rejection after corneal graft surgery. Appropriate, human-specific, decellularization techniques and high-resolution, non-destructive analysis systems are required to ensure reproducible outputs can be achieved. If robust treatment and characterization processes can be developed, DCs could offer a supplement to the donor corneal pool, alongside superior cell culture systems for pharmacology, toxicology and drug discovery studies.
Sponsor: Funding from E-TERM Engineering, Tissue Engineering and Regenerative Medicine (Grant number: EP/I017801/1) are gratefully acknowledged.
Version: Published
DOI: 10.3390/jfb4030114
URI: https://dspace.lboro.ac.uk/2134/26840
Publisher Link: https://doi.org/10.3390/jfb4030114
ISSN: 2079-4983
Appears in Collections:Published Articles (Mechanical, Electrical and Manufacturing Engineering)

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