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Title: Controlling polymer capture and translocation by electrostatic polymer-pore interactions
Authors: Buyukdagli, Sahin
Ala-Nissila, Tapio
Keywords: Electrostatics
Nanomaterials
Electrophoresis
Polyelectrolytes
Thermodynamic functions
Issue Date: 2017
Publisher: AIP Publishing © The Authors
Citation: BUYUKDAGLI, S. and ALA-NISSILA, T., 2017. Controlling polymer capture and translocation by electrostatic polymer-pore interactions. The Journal of Chemical Physics, 147 (11), 114904.
Abstract: Polymer translocation experiments typically involve anionic polyelectrolytes such as DNA molecules driven through negatively charged nanopores. Quantitative modeling of polymer capture to the nanopore followed by translocation therefore necessitates the consideration of the electrostatic barrier resulting from like-charge polymer-pore interactions. To this end, in this work we couple mean-field level electrohydrodynamic equations with the Smoluchowski formalism to characterize the interplay between the electrostatic barrier, the electrophoretic drift, and the electro-osmotic liquid flow. In particular, we find that due to distinct ion density regimes where the salt screening of the drift and barrier effects occurs, there exists a characteristic salt concentration maximizing the probability of barrier-limited polymer capture into the pore. We also show that in the barrier-dominated regime, the polymer translocation time τ increases exponentially with the membrane charge and decays exponentially fast with the pore radius and the salt concentration. These results suggest that the alteration of these parameters in the barrier-driven regime can be an efficient way to control the duration of the translocation process and facilitate more accurate measurements of the ionic current signal in the pore.
Description: This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. The following article appeared in The Journal of Chemical Physics, 147 (11), 114904. and may be found at https://doi.org/10.1063/1.5004182.
Version: Accepted for publication
DOI: 10.1063/1.5004182
URI: https://dspace.lboro.ac.uk/2134/26996
Publisher Link: https://doi.org/10.1063/1.5004182
ISSN: 0021-9606
Appears in Collections:Published Articles (Maths)

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