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Title: Influence of muscle mass in the assessment of lower limb strength in COPD: validation of the prediction equation
Authors: Trethewey, Ruth
Esliger, Dale W.
Petherick, Emily S.
Evans, Rachel A.
Greening, N.
James, B.
Kingsnorth, Andrew P.
Morgan, Mike
Orme, Mark W.
Sherar, Lauren B.
Singh, Sally
Toms, N.
Steiner, Michael
Issue Date: 2017
Publisher: BMJ Publishing Group © Article author(s)
Citation: TRETHEWEY, R. ... et al, 2017. Influence of muscle mass in the assessment of lower limb strength in COPD: validation of the prediction equation. Thorax, doi: 10.1136/thoraxjnl-2016-209870.
Abstract: Absence of established reference values limits application of quadriceps maximal voluntary contraction (QMVC) measurement. The impact of muscle mass inclusion in predictions is unclear. Prediction equations encompassing gender, age and size with (FFM+) and without (FFM−), derived in healthy adults (n=175), are presented and compared in two COPD cohorts recruited from primary care (COPD-PC, n=112) and a complex care COPD clinic (COPD-CC, n=189). Explained variance was comparable between the prediction models (R2: FFM+: 0.59, FFM−: 0.60) as were per cent predictions in COPD-PC (88.8%, 88.3%). However, fat-free mass inclusion reduced the prevalence of weakness in COPD, particularly in COPD-CC where 11.9% fewer were deemed weak.
Description: This article was published in the journal, Thorax [BMJ Publishing Group © Article author(s)] and the definitive version is available at: https://doi.org/10.1136/thoraxjnl-2016-209870
Version: Accepted for publication
DOI: 10.1136/thoraxjnl-2016-209870
URI: https://dspace.lboro.ac.uk/2134/27020
Publisher Link: https://doi.org/10.1136/thoraxjnl-2016-209870
ISSN: 0040-6376
Appears in Collections:Published Articles (Sport, Exercise and Health Sciences)

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