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An oxygen transport model of human bone marrow for hemolytic sickle cell anemia
The human bone marrow (BM) is a complicated tissue with intricate vascular and heterogeneous
extravascular (tissue) architecture. Oxygen is an important modulator of differentiation and proliferation
of the BM hematopoietic cells under normal and pathological conditions. Currently, due to the
inaccessibility of the BM, it is not possible to measure the spatial distribution of the oxygen tension
(concentration) levels in the tissue. Thus, the present treatise utilizes mathematical modeling to offer a
greater insight on the effects of oxygen on the BM cellular components. Here, we present simulation
results that are correlated with known in vivo data of BM along with proposing a model for the two state
description of allosteric hemoglobin molecule under hemolytic sickle cell anemia condition of BM.
Funding
Commonwealth Scholarship Commission.
History
School
- Aeronautical, Automotive, Chemical and Materials Engineering
Department
- Chemical Engineering
Published in
Journal of Chemical EngineeringVolume
24Pages
7 - 7Citation
ISLAM, M. and KUMAR, R., 2006. An oxygen transport model of human bone marrow for hemolytic sickle cell anemia. Journal of Chemical Engineering (Bangladesh), 24 (1), pp.7-13.Publisher
Bangladesh Journals OnlineVersion
- AM (Accepted Manuscript)
Publisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/Publication date
2006ISSN
2221-7436eISSN
2408-8617Publisher version
Language
- en