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Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/27310

Title: An oxygen transport model of human bone marrow for hemolytic sickle cell anemia
Authors: Islam, M. Ahsanul
Kumar, R.
Issue Date: 2006
Publisher: Bangladesh Journals Online
Citation: ISLAM, M. and KUMAR, R., 2006. An oxygen transport model of human bone marrow for hemolytic sickle cell anemia. Journal of Chemical Engineering (Bangladesh), 24 (1), pp.7-13.
Abstract: The human bone marrow (BM) is a complicated tissue with intricate vascular and heterogeneous extravascular (tissue) architecture. Oxygen is an important modulator of differentiation and proliferation of the BM hematopoietic cells under normal and pathological conditions. Currently, due to the inaccessibility of the BM, it is not possible to measure the spatial distribution of the oxygen tension (concentration) levels in the tissue. Thus, the present treatise utilizes mathematical modeling to offer a greater insight on the effects of oxygen on the BM cellular components. Here, we present simulation results that are correlated with known in vivo data of BM along with proposing a model for the two state description of allosteric hemoglobin molecule under hemolytic sickle cell anemia condition of BM.
Sponsor: Commonwealth Scholarship Commission.
Version: Accepted for publication
DOI: 10.3329/jce.v24i0.5577
URI: https://dspace.lboro.ac.uk/2134/27310
Publisher Link: https://doi.org/10.3329/jce.v24i0.5577
ISSN: 2221-7436
Appears in Collections:Closed Access (Chemical Engineering)

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