A method of calculating the RP-HPLC retention indices,
based on the alkylarylketone scale, has been developed. The
retention indices are calculated from the molecular
structure of a compound as the sum of the parent
contribution, the parent index, the substituent
contributions, the substituent indices, and terms to account
for the interactions between substituents, the interaction
A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy at Loughborough University.