A range of conjugates which focused on bisphosphonates as delivery
molecules and on oestrogens as resorption inhibitors were synthesised.
Various moieties were coupled through an ester linkage to bisphosphonates
which were then converted to the corresponding bisphosphonic acids. This
ester linkage was considered to be readily hydrolysable under normal
physiological conditions. [Continues.]
A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy at Loughborough University.