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Title: Biocompatibility assessment of conducting PANI/Chitosan nanofibers for wound healing applications
Authors: Moutsatsou, Panagiota
Coopman, Karen
Georgiadou, Stella
Keywords: Polyaniline
Electrospun nanofibres
Wound dressing
Conductive fibres
Issue Date: 2017
Publisher: MDPI AG © by the authors
Citation: MOUTSATSOU, P., COOPMAN, K. and GEORGIADOU, S., 2017. Biocompatibility assessment of conducting PANI/Chitosan nanofibers for wound healing applications. Polymers, 9 (12), 687.
Abstract: As electroactive polymers have recently presented potential in applications in the tissue engineering and biomedical field, this study is aiming at the fabrication of composite nanofibrous membranes containing conducting polyaniline and at the evaluation of their biocompatibility. For that purpose, conducting polyaniline–chitosan (PANI/CS) defect free nanofibres of different ratios (1:3; 3:5 and 1:1) were produced with the electrospinning method. They were characterized as for their morphology, hydrophilicity and electrical conductivity. The membranes were then evaluated for their cellular biocompatibility in terms of cell attachment, morphology and cell proliferation. The effect of the PANI content on the membrane properties is discussed. Increase in PANI content resulted in membranes with higher hydrophobicity and higher electrical conductivity. It was found that none of the membranes showed any toxic effects on osteoblasts and fibroblasts, and that they all supported cell attachment and growth, even to a greater extent than tissue culture plastic. The membrane with the PANI/CS ratio 1:3 supports better cell attachment and proliferation for both cell lines due to a synergistic effect of hydrophilicity retention due to the high chitosan content and the conductivity that PANI introduced to the membrane.
Description: This is an Open Access Article. It is published by MDPI under the Creative Commons Attribution 4.0 International Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/
Sponsor: This work has been funded by the Loughborough University Graduate School.
Version: Published
DOI: 10.3390/polym9120687
URI: https://dspace.lboro.ac.uk/2134/27818
Publisher Link: https://doi.org/10.3390/polym9120687
ISSN: 2073-4360
Appears in Collections:Published Articles (Chemical Engineering)

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