Ushaped HDL_mortality_clean_ATVB_2017 combined.pdf (209.76 kB)
High density lipoprotein cholesterol and mortality: too much of a good thing?
journal contribution
posted on 2018-01-05, 10:41 authored by Mark Hamer, Gary O'Donovan, Emmanuel StamatakisObjective: To examine the shape of the association between high density lipoprotein cholesterol (HDL-C) and mortality in a large general population sample. Approach and results: Adult participants (n=37,059, age= 57.7±11.9 years, 46.8% men) were recruited from general population household-based surveys (Health Survey for England and Scottish Health Survey). Individual participant data were linked with the British National Health Service Central Registry to record mortality. There were 2,250 deaths from all causes during 326,016 person-years of follow-up. When compared to the reference category (HDL-C = 1.5 – 1.99 mmol·L-1) a U-shaped association was apparent for all-cause mortality, with elevated risk in participants with the lowest (Hazard ratio=1.23, 95% CI, 1.06, 1.44) and highest (1.25; 0.97, 1.62) HDL-C concentration. Associations for cardiovascular disease were linear, and elevated risk was observed in those with the lowest HDL-C concentration (1.49; 1.15, 1.94). Conclusions: A U-shaped association was observed between HDL-C and mortality in a large general population sample.
Funding
Stamatakis is funded by the National Health and Medical Research Council (NHMRC) through a Senior Research Fellowship.
History
School
- Sport, Exercise and Health Sciences
Published in
Arteriosclerosis, Thrombosis, and Vascular BiologyCitation
HAMER, M., O'DONOVAN, G. and STAMATAKIS, E., 2018. High density lipoprotein cholesterol and mortality: too much of a good thing?. Arteriosclerosis, Thrombosis, and Vascular Biology, 38, pp. 669-672.Publisher
© American Heart AssociationVersion
- AM (Accepted Manuscript)
Publisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/Acceptance date
2017-12-27Publication date
2018Notes
This paper was published in the journal Arteriosclerosis, Thrombosis, and Vascular Biology and the definitive published version is available at https://doi.org/10.1161/ATVBAHA.117.310587.ISSN
1079-5642eISSN
1524-4636Publisher version
Language
- en