The purpose of the work was to study the synthesis of the pyrrolo[2,1-α]phthalazine system, and of the related systems, and routes to
substituted derivatives with a view to producing compounds of potential
antihypertensive activity. The effect of substitution particularly at
and in the region of the 6-position of pyrrolo[2,1-α]phthalazine, was
of interest, by analogy with the substituted phthalazine antihypertensive
agent, hydralazine. [Continues.]
A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy at Loughborough University.