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Title: Refractive error is associated with intracranial volume
Authors: Takeuchi, Hikaru
Taki, Yasuyuki
Nouchi, Rui
Yokoyama, Ryoichi
Kotozaki, Yuka
Nakagawa, Seishu
Sekiguchi, Atsushi
Iizuka, Kunio
Yamamoto, Yuki
Hanawa, Sugiko
Araki, Tsuyoshi
Miyauchi, Carlos M.
Shinada, Takamitsu
Sakaki, Kohei
Sassa, Yuko
Nozawa, Takayuki
Ikeda, Shigeyuki
Yokota, Susumu
Magistro, Daniele
Kawashima, Ryuta
Keywords: Cognitive control
Development of the nervous system
Issue Date: 2018
Publisher: Nature Publishing Group © The Author(s)
Citation: TAKEUCHI, H. ... et al, 2018. Refractive error is associated with intracranial volume. Scientific Reports, 8, Article number: 175.
Abstract: Myopia is part of the spectrum of refractive error. Myopia is associated with psychometric intelligence and, the link between brain anatomy and myopia has been hypothesized. Here we aimed to identify the associations between brain structures and refractive error in developed young adults. In a study cohort of 1,319 normal educated young adults, the refractive error showed a significant negative correlation with total intracranial volume and total cerebrospinal fluid (CSF) volume but not with total gray matter volume (GMV) or total white matter volume (WMV). Time spent studying was associated with refractive error but could not explain the aforementioned associations with brain volume parameters. The R2 values of the simple regression between spherical equivalent and outcome variables for each sex in non-whole brain imaging analyses were less than 0.05 in all cases and thus were weak. Psychometric intelligence was not associated with refractive error or total CSF volume, but it weakly positively correlated with total GMV and total WMV in this study population. Thus, refractive error appears to be primarily (weakly) associated with the volume of the cranium, whereas psychometric intelligence was associated with the volume of the brain.
Description: This is an Open Access Article. It is published by Nature Publishing Group under the Creative Commons Attribution 4.0 International Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/
Sponsor: This study was supported by a Grant-in-Aid for Young Scientists (B) (KAKENHI 23700306) and a Grant-in-Aid for Young Scientists (A) (KAKENHI 25700012) from the Ministry of Education, Culture, Sports, Science, and Technology.
Version: Published
DOI: 10.1038/s41598-017-18669-0
URI: https://dspace.lboro.ac.uk/2134/28084
Publisher Link: https://doi.org/10.1038/s41598-017-18669-0
Appears in Collections:Published Articles (Sport, Exercise and Health Sciences)

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