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Title: Scanning the horizon for high value-add manufacturing science: Accelerating manufacturing readiness for the next generation of disruptive, high-value curative cell therapeutics
Authors: Hourd, Paul C.
Williams, David J.
Keywords: Disruptive
Gene-editing
Induced pluripotent stem cells
Manufacturing readiness
Manufacturing science
Regenerative medicine
Technology readiness
Issue Date: 2018
Publisher: Elsevier (© 2018 International Society for Cellular Therapy)
Citation: HOURD, P.C. and WILLIAMS, D.J., 2018. Scanning the horizon for high value-add manufacturing science: Accelerating manufacturing readiness for the next generation of disruptive, high-value curative cell therapeutics. Cytotherapy, 20 (5), pp.759-767.
Abstract: Since the Regenerative Medicine sector entered the second phase of its development (RegenMed 2.0) more than a decade ago, there is increasing recognition that current technology innovation trajectories will drive the next translational phase towards the production of disruptive, high value curative cell and gene based regenerative medicines. In this short report, a long lens look within the pluripotent stem cell therapeutic space, both embryonic and induced, is used to gain early insights on where critical technology and manufacturing challenges may emerge. The report offers a future perspective on the development and innovation that will be needed within manufacturing science to add value in the production and commercialisation of the next generation of advanced cell therapies and precision medicines.
Description: This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
Sponsor: The work described in this article was supported by the UK Regenerative Medicine Platform as part of the work of the Pluripotent Stem Cell Platform (Award MR/L012537/1) focussed on horizon scanning with respect to manufacturing.
Version: Published
DOI: 10.1016/j.jcyt.2018.01.007
URI: https://dspace.lboro.ac.uk/2134/28153
Publisher Link: https://doi.org/10.1016/j.jcyt.2018.01.007
ISSN: 1465-3249
Appears in Collections:Published Articles (Mechanical, Electrical and Manufacturing Engineering)

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